Recurrent venous thromboembolism in patients on low-intensity or conventional-intensity warfarin according to the presence of one or more thrombophilias
| Thrombophilia . | Recurrent venous thromboembolism . | ||
|---|---|---|---|
| Events/n . | Percentage per patient-year (95% CI) . | Hazard ratio (95% CI) . | |
| Factor V Leiden | 3*/171 | 0.8 (0.2-2.2) | 0.7 (0.2-2.6) |
| Prothrombin gene mutation | 0/60 | 0.0 (0.0-2.9) | 0 (nc) |
| Antiphospholipid antibody | 3†/54 | 2.3 (0.4-6.7) | 2.9 (0.8-10.5) |
| Antithrombin deficiency | 0/23 | 0.0 (0.0-7.0) | 0 (nc) |
| Factor VIII elevation | 1/67 | 0.7 (0.0-4.0) | 0.7 (0.1-5.4) |
| Factor XI elevation | 1/66 | 0.6 (0.0-3.5) | 0.7 (0.1-5.0) |
| Homocysteine elevation | 1/64 | 0.7 (0.0-3.9) | 0.7 (0.1-5.3) |
| No. of abnormalities | |||
| None | 7‡/280 | 1.1 (0.5-2.3) | 1.0 (referent) |
| 1 | 5§/270 | 0.8 (0.3-1.9) | 0.7 (0.2-2.3) |
| 2 | 2‖/91 | 1.0 (0.1-3.5) | 0.8 (0.2-4.1) |
| 1 or more | 7/381 | 0.8 (0.3-1.7) | 0.7 (0.3-2.0) |
| 2 or more | 2/111 | 0.8 (0.1-2.9) | 0.7 (0.2-3.4) |
| All patients | 14/661 | 0.9 (0.6-1.5) | |
| Thrombophilia . | Recurrent venous thromboembolism . | ||
|---|---|---|---|
| Events/n . | Percentage per patient-year (95% CI) . | Hazard ratio (95% CI) . | |
| Factor V Leiden | 3*/171 | 0.8 (0.2-2.2) | 0.7 (0.2-2.6) |
| Prothrombin gene mutation | 0/60 | 0.0 (0.0-2.9) | 0 (nc) |
| Antiphospholipid antibody | 3†/54 | 2.3 (0.4-6.7) | 2.9 (0.8-10.5) |
| Antithrombin deficiency | 0/23 | 0.0 (0.0-7.0) | 0 (nc) |
| Factor VIII elevation | 1/67 | 0.7 (0.0-4.0) | 0.7 (0.1-5.4) |
| Factor XI elevation | 1/66 | 0.6 (0.0-3.5) | 0.7 (0.1-5.0) |
| Homocysteine elevation | 1/64 | 0.7 (0.0-3.9) | 0.7 (0.1-5.3) |
| No. of abnormalities | |||
| None | 7‡/280 | 1.1 (0.5-2.3) | 1.0 (referent) |
| 1 | 5§/270 | 0.8 (0.3-1.9) | 0.7 (0.2-2.3) |
| 2 | 2‖/91 | 1.0 (0.1-3.5) | 0.8 (0.2-4.1) |
| 1 or more | 7/381 | 0.8 (0.3-1.7) | 0.7 (0.3-2.0) |
| 2 or more | 2/111 | 0.8 (0.1-2.9) | 0.7 (0.2-3.4) |
| All patients | 14/661 | 0.9 (0.6-1.5) | |