The frequency of the individuals carrying DHFR haplotypes among patients with ALL with and without event
| Haplotype . | Event, no. (%) . | Nonevent, no. (%) . | P* . | ||
|---|---|---|---|---|---|
| + . | − . | + . | − . | ||
| *1 | 29 (53.7) | 25 (46.3) | 86 (38.9) | 135 (61.1) | .03 |
| *3 | 28 (51.9) | 26 (48.1) | 125 (56.6) | 96 (43.4) | .5 |
| *4 | 4 (7.4) | 50 (92.6) | 52 (23.5) | 169 (76.5) | .009 |
| *5 | 25 (46.3) | 29 (53.7) | 115 (52.0) | 106 (48.0) | .4 |
| Haplotype . | Event, no. (%) . | Nonevent, no. (%) . | P* . | ||
|---|---|---|---|---|---|
| + . | − . | + . | − . | ||
| *1 | 29 (53.7) | 25 (46.3) | 86 (38.9) | 135 (61.1) | .03 |
| *3 | 28 (51.9) | 26 (48.1) | 125 (56.6) | 96 (43.4) | .5 |
| *4 | 4 (7.4) | 50 (92.6) | 52 (23.5) | 169 (76.5) | .009 |
| *5 | 25 (46.3) | 29 (53.7) | 115 (52.0) | 106 (48.0) | .4 |
The frequency of carriers and noncarriers of a given haplotype sums up to 100% in each group of patients. All observed haplotype pairs containing haplotype *1, *3, *4 or *5 contributed to the estimation of the number of the respective carriers. Respective EFS curves for the carriers of haplotypes *1 and *4 are given in Figure 2C and D.
P value is estimated by log-rank test.