Tissues were fixed in 10% neutral buffered formalin, trimmed, paraffin-embedded, sectioned, and stained using routine hematoxylin and eosin. Scores represent the average values of each animal group. All tissues were scored using the following scale: no neoplastic cells (−); minimal (+) corresponds to an infiltrate of 0 to 5 cells in radius; mild (++) corresponds to an infiltrate of 6 to 10 cells in radius; moderate (+++) corresponds to an infiltrate of 11 to 15 cells in radius; maximal (++++) corresponds to an infiltrate of 16 or more cells in radius. Data represent the averages from the mouse groups of tumor cell infiltration in each tissue.