Cox model for overall survival using transplantation baseline characteristics
| Variable . | Overall (n = 488)* . | MRD (n = 202)* . | MUD/MM (n = 286)* . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Age, 50 y or younger vs older than 50 y | 0.58 | 0.43-0.78 | < .001 | 0.48 | 0.30-0.78 | .003 | 0.64 | 0.43-0.94 | .03 |
| Transplant risk, low vs high | 0.79 | 0.56-1.11 | .18 | 1.01 | 0.60-1.71 | .97 | 0.69 | 0.44-1.09 | .11 |
| MRD vs MUD/MM | 0.70 | 0.50-0.97 | .03 | ||||||
| PBSC vs BM | 1.38 | 0.93-2.04 | .11 | 1.53 | 0.76-3.08 | .23 | 1.33 | 0.83-2.15 | .23 |
| Donor-recipient sex: MF or FM vs MM or FF | 1.10 | 0.84-1.45 | .50 | 0.73 | 0.46-1.17 | .19 | 1.37 | 0.98-1.93 | .07 |
| Second/subsequent vs first transplantation | 1.01 | 0.54-1.87 | .98 | 0.78 | 0.31-2.00 | .60 | 1.21 | 0.52-2.81 | .65 |
| Year of transplantation, 2002 or later vs before 2002 | 0.58 | 0.39-0.85 | .006 | 0.43 | 0.22-0.84 | .01 | 0.65 | 0.39-1.10 | .11 |
| Tac/Sir/Mtx vs Tac/Mtx | 1.11 | 0.80-1.55 | .54 | 1.68 | 0.63-4.49 | .30 | 1.07 | 0.74-1.55 | .72 |
| Tac/Sir vs Tac/Mtx | 0.54 | 0.36-0.81 | .003 | 0.73 | 0.40-1.33 | .30 | 0.45 | 0.24-0.82 | .009 |
| Variable . | Overall (n = 488)* . | MRD (n = 202)* . | MUD/MM (n = 286)* . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Age, 50 y or younger vs older than 50 y | 0.58 | 0.43-0.78 | < .001 | 0.48 | 0.30-0.78 | .003 | 0.64 | 0.43-0.94 | .03 |
| Transplant risk, low vs high | 0.79 | 0.56-1.11 | .18 | 1.01 | 0.60-1.71 | .97 | 0.69 | 0.44-1.09 | .11 |
| MRD vs MUD/MM | 0.70 | 0.50-0.97 | .03 | ||||||
| PBSC vs BM | 1.38 | 0.93-2.04 | .11 | 1.53 | 0.76-3.08 | .23 | 1.33 | 0.83-2.15 | .23 |
| Donor-recipient sex: MF or FM vs MM or FF | 1.10 | 0.84-1.45 | .50 | 0.73 | 0.46-1.17 | .19 | 1.37 | 0.98-1.93 | .07 |
| Second/subsequent vs first transplantation | 1.01 | 0.54-1.87 | .98 | 0.78 | 0.31-2.00 | .60 | 1.21 | 0.52-2.81 | .65 |
| Year of transplantation, 2002 or later vs before 2002 | 0.58 | 0.39-0.85 | .006 | 0.43 | 0.22-0.84 | .01 | 0.65 | 0.39-1.10 | .11 |
| Tac/Sir/Mtx vs Tac/Mtx | 1.11 | 0.80-1.55 | .54 | 1.68 | 0.63-4.49 | .30 | 1.07 | 0.74-1.55 | .72 |
| Tac/Sir vs Tac/Mtx | 0.54 | 0.36-0.81 | .003 | 0.73 | 0.40-1.33 | .30 | 0.45 | 0.24-0.82 | .009 |
Wald test P value for the coefficient.
MRD indicates matched, related donor; MUD/MM, matched, unrelated donor or mismatched donor; PBSC, peripheral blood stem cell; BM, bone marrow.