Signal transduction antibody array
| Designation . | Description . | VEGF-A165/VEGF-A121 (fold) . |
|---|---|---|
| Stat2 | Signal transducer and activator of transcription 2, 113 kDa | 9.17 |
| Stat6 | Signal transducer and activator of transcription 6, interleukin-4 induced | 5.36 |
| Ret | Ret proto-oncogene | 3.23 |
| ZO-1 | Tight junction protein 1 (zona occuludens 1) | 2.58 |
| Flt3/2 | fms-related tyrosine kinase 3/2 | 2.38 |
| TP73 | Tumor protein p73 | 2.16 |
| VAV | Vav oncogene | 2.06 |
| p38 | Mitogen activated protein kinase 14 | 1.99 |
| VEGFR-1 | fms-related tyrosine kinase 1 | 1.66 |
| SHIP | Inositol polyphosphate-5-phosphatase, 145 kDa | 1.66 |
| PLC-γ | Phospholipase C-γ | 1.60 |
| PECAM-1 | Platelet/endothelial cell adhesion molecule 1 | 1.49 |
| Stat1 | Signal transducer and activator of transcription 1, 91 kDa | 1.42 |
| c-Fgr | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 1.36 |
| c-Cbl | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 1.31 |
| Tuberin | Tuberous sclerosis 2 | 1.24 |
| P63 | Tumor protein p73-like | 1.17 |
| ERK2 | Mitogen-activated protein kinase 1 | 0.93 |
| Ets-1/2 | v-ets erythroblastosis virus E26 oncogene homolog 1/2 | 0.86 |
| HSP-70 | Heat shock 70 kDa protein | 0.81 |
| c-Jun | Jun oncogene | 0.80 |
| c-Src | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.74 |
| lkB kinase-β | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 0.74 |
| DSG | Desmoglein | 0.51 |
| Designation . | Description . | VEGF-A165/VEGF-A121 (fold) . |
|---|---|---|
| Stat2 | Signal transducer and activator of transcription 2, 113 kDa | 9.17 |
| Stat6 | Signal transducer and activator of transcription 6, interleukin-4 induced | 5.36 |
| Ret | Ret proto-oncogene | 3.23 |
| ZO-1 | Tight junction protein 1 (zona occuludens 1) | 2.58 |
| Flt3/2 | fms-related tyrosine kinase 3/2 | 2.38 |
| TP73 | Tumor protein p73 | 2.16 |
| VAV | Vav oncogene | 2.06 |
| p38 | Mitogen activated protein kinase 14 | 1.99 |
| VEGFR-1 | fms-related tyrosine kinase 1 | 1.66 |
| SHIP | Inositol polyphosphate-5-phosphatase, 145 kDa | 1.66 |
| PLC-γ | Phospholipase C-γ | 1.60 |
| PECAM-1 | Platelet/endothelial cell adhesion molecule 1 | 1.49 |
| Stat1 | Signal transducer and activator of transcription 1, 91 kDa | 1.42 |
| c-Fgr | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 1.36 |
| c-Cbl | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 1.31 |
| Tuberin | Tuberous sclerosis 2 | 1.24 |
| P63 | Tumor protein p73-like | 1.17 |
| ERK2 | Mitogen-activated protein kinase 1 | 0.93 |
| Ets-1/2 | v-ets erythroblastosis virus E26 oncogene homolog 1/2 | 0.86 |
| HSP-70 | Heat shock 70 kDa protein | 0.81 |
| c-Jun | Jun oncogene | 0.80 |
| c-Src | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.74 |
| lkB kinase-β | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 0.74 |
| DSG | Desmoglein | 0.51 |
Quantification of tyrosine phosphorylation of different signaling molecules in PAE/VEGFR-2, NRP1 cells treated with VEGF-A165 or VEGF-A121 for 5 minutes. Lysates of differently treated cells were incubated on signal transduction antibody arrays. The difference in fold induction in response to VEGF-A165 over VEGF-A121 is shown. Protein designation and description are given according to Entrez.