Biotinylated magnetic bead study results
| ID . | Mean HbA1c fraction* (HbA1c/HbA+HbA1c) . | RBC mean cell age, days . | HbA1c in vivo synthesis rateBiotinylated RBC slope rate (fraction/day × 10−4) . | TfR(+) cell HbA1c fraction (HbA1c/HbA+HbA1c) . |
|---|---|---|---|---|
| NDM 1 | 0.052 | 51.2 | 6.5 | 0.0073 |
| NDM 2 | 0.052 | 49.8 | 6.1 | 0.0074 |
| NDM 3 | 0.047 | 38.4 | 4.8 | 0.0074 |
| NDM 4 | 0.054 | 51.6 | 7.3 | 0.0063 |
| NDM 5 | 0.064 | 53.8 | 8.0 | 0.0074 |
| NDM 6 | 0.058 | 59.5 | 6.2 | 0.0084 |
| Mean ± SD | 0.055 ± 0.006 | 50.7 ± 6.9 | 6.5 ± 1.1 | 0.007 ± 0.001 |
| DM 1 | 0.129 | 52.6 | 21.4 | 0.0230 |
| DM 2 | 0.081 | 39.4 | 11.9 | 0.0085 |
| DM 3 | 0.056 | 45.4 | 5.5 | 0.0072 |
| DM 4 | 0.080 | 44.4 | 11.5 | 0.0105 |
| DM 5 | 0.082 | 49.3 | 8.1 | 0.0152 |
| DM 6 | 0.089 | 56.0 | 10.5 | 0.0148 |
| Mean ± SD | 0.086 ± 0.024 | 47.9 ± 6.0 | 11.5 ± 5.4 | 0.013 ± 0.006 |
| ID . | Mean HbA1c fraction* (HbA1c/HbA+HbA1c) . | RBC mean cell age, days . | HbA1c in vivo synthesis rateBiotinylated RBC slope rate (fraction/day × 10−4) . | TfR(+) cell HbA1c fraction (HbA1c/HbA+HbA1c) . |
|---|---|---|---|---|
| NDM 1 | 0.052 | 51.2 | 6.5 | 0.0073 |
| NDM 2 | 0.052 | 49.8 | 6.1 | 0.0074 |
| NDM 3 | 0.047 | 38.4 | 4.8 | 0.0074 |
| NDM 4 | 0.054 | 51.6 | 7.3 | 0.0063 |
| NDM 5 | 0.064 | 53.8 | 8.0 | 0.0074 |
| NDM 6 | 0.058 | 59.5 | 6.2 | 0.0084 |
| Mean ± SD | 0.055 ± 0.006 | 50.7 ± 6.9 | 6.5 ± 1.1 | 0.007 ± 0.001 |
| DM 1 | 0.129 | 52.6 | 21.4 | 0.0230 |
| DM 2 | 0.081 | 39.4 | 11.9 | 0.0085 |
| DM 3 | 0.056 | 45.4 | 5.5 | 0.0072 |
| DM 4 | 0.080 | 44.4 | 11.5 | 0.0105 |
| DM 5 | 0.082 | 49.3 | 8.1 | 0.0152 |
| DM 6 | 0.089 | 56.0 | 10.5 | 0.0148 |
| Mean ± SD | 0.086 ± 0.024 | 47.9 ± 6.0 | 11.5 ± 5.4 | 0.013 ± 0.006 |
HbA1c fraction is shown as the mean of serial determinations at each time point throughout the biotin labeling study.