Clinical and phenotypic data in 47 cases of pDC neoplasms
| Case no. . | Age, y/sex . | Site of involvement . | CD4 . | CD45RA . | CD43 . | CD56 . | CD123 . | TCL1 . | TdT . | |
|---|---|---|---|---|---|---|---|---|---|---|
| CD4+CD56+ hematodermic neoplasm | ||||||||||
| 1 | 77/F | Skin | + | + | + | + | Scat'rd+ | nd | Scat'rd+ | |
| 2 | 73/F | Skin | + | nd | nd | − | nd | nd | + | |
| 3 | 61/M | Skin and bone marrow | + | + | + | + (30%) | + | + | − | |
| 4 | 67/M | Skin | + | nd | + | + | + | + | − | |
| 5 | 60/M | Skin | + | + | + | + | + | + | + | |
| 6 | 80/M | Bone marrow | + | + | + | + | + | + | – | |
| 7 | 51/M | Bone marrow | + | + | + | + | + | nd | – | |
| 8 | 75/M | Skin | + | + | + | + | – | + | – | |
| 9 | 78/F | Spleen | + | + | + | + | + | + | – | |
| 10 | 80/M | Skin | + | + | + | – | + | + | – | |
| 11 | 78/M | Bone marrow | + | + | + | + | + | + | – | |
| 12 | 45/F | na | + | + | + | + | + | + | – | |
| 13 | 58/M | Bone marrow | + | + | + | + | + | + | – | |
| 14 | 71/M | Skin | + | + | + | + | + | + | + | |
| 15 | 72/M | Skin | + | + | + | + | + | nd | – | |
| 16 | 30/M | Skin | + | + | + | +/− | + | + | −/+ | |
| 17 | na | na | + | + | + | +/− | + | + | +/− | |
| 18 | 31/M | Skin | + | + | + | + | + | + | −/+ | |
| 19 | 57 M | Skin, lymph node, and bone marrow | + | nd | + | + | nd | nd | + | |
| 20 | 68 F | Skin | + | nd | + | + | nd | nd | + | |
| 21 | 12 F | Skin | + | nd | + | + | nd | nd | + | |
| 22 | 25/F | Skin | + | nd | + | + | + | + | nd | |
| 23 | 77/M | Skin | + | + | + | + | + | + | − | |
| 24 | 35/F | Skin | + | nd | + | + | + | + | − | |
| 25 | 80/M | Skin | + | nd | nd | + | nd | nd | nd | |
| 26 | 96/F | Skin | + | nd | + | + | + | + | + (30%) | |
| 27 | 73/M | Skin | + | nd | + | + | + | + | − | |
| 28 | 76/M | Skin | + | nd | + | + | + | + | + (50%) | |
| 29 | 54/F | Skin | + | nd | − | + | + | + | + (80%) | |
| 30 | 71/M | Skin | + | nd | + | + | + | + | − | |
| 31 | 63/M | Skin | + | nd | nd | + | + | + | + (10%) | |
| 32 | 8/M | Skin | + | + | + | + | + | + | − | |
| 33 | 64/M | Lymph node | + | nd | + | + | nd | + | + | |
| 34 | 84/M | Skin | + | + | + | + | + | + | − | |
| 35 | 60/F | Skin | + | nd | nd | + | nd | nd | nd | |
| 36 | 83/M | Skin | + | nd | nd | + | + | + | − | |
| 37 | 75/M | Skin | + | nd | + | + | + | + | − | |
| 38 | 25/M | Skin | + | nd | nd | + | + | + | − | |
| 39 | 70/F | Skin | + | nd | + | + | nd | + | − | |
| 40 | 88/F | Skin | + | + | + | + | + | + | + (10%) | |
| 41 | 72/M | Skin | + | + | + | + | + | + | − | |
| pDC proliferations associated with a myeloproliferative disorder | ||||||||||
| 42 | 52/M | Lymph node | + | + | + | (+) | + | + | − | |
| 43 | 63/F | Lymph node | + | + | + | (+) | + | (+) | − | |
| 44 | 24/M | Lymph node and skin | + | + | + | − | + | (+) | − | |
| 45 | 62/F | Lymph node | + | + | + | − | + | (+) | − | |
| 46 | 65/M | Lymph node | + | nd | + | (+) | + | + | − | |
| 47 | 71/M | Bone marrow | + | + | + | − | + | nd | − |
| Case no. . | Age, y/sex . | Site of involvement . | CD4 . | CD45RA . | CD43 . | CD56 . | CD123 . | TCL1 . | TdT . | |
|---|---|---|---|---|---|---|---|---|---|---|
| CD4+CD56+ hematodermic neoplasm | ||||||||||
| 1 | 77/F | Skin | + | + | + | + | Scat'rd+ | nd | Scat'rd+ | |
| 2 | 73/F | Skin | + | nd | nd | − | nd | nd | + | |
| 3 | 61/M | Skin and bone marrow | + | + | + | + (30%) | + | + | − | |
| 4 | 67/M | Skin | + | nd | + | + | + | + | − | |
| 5 | 60/M | Skin | + | + | + | + | + | + | + | |
| 6 | 80/M | Bone marrow | + | + | + | + | + | + | – | |
| 7 | 51/M | Bone marrow | + | + | + | + | + | nd | – | |
| 8 | 75/M | Skin | + | + | + | + | – | + | – | |
| 9 | 78/F | Spleen | + | + | + | + | + | + | – | |
| 10 | 80/M | Skin | + | + | + | – | + | + | – | |
| 11 | 78/M | Bone marrow | + | + | + | + | + | + | – | |
| 12 | 45/F | na | + | + | + | + | + | + | – | |
| 13 | 58/M | Bone marrow | + | + | + | + | + | + | – | |
| 14 | 71/M | Skin | + | + | + | + | + | + | + | |
| 15 | 72/M | Skin | + | + | + | + | + | nd | – | |
| 16 | 30/M | Skin | + | + | + | +/− | + | + | −/+ | |
| 17 | na | na | + | + | + | +/− | + | + | +/− | |
| 18 | 31/M | Skin | + | + | + | + | + | + | −/+ | |
| 19 | 57 M | Skin, lymph node, and bone marrow | + | nd | + | + | nd | nd | + | |
| 20 | 68 F | Skin | + | nd | + | + | nd | nd | + | |
| 21 | 12 F | Skin | + | nd | + | + | nd | nd | + | |
| 22 | 25/F | Skin | + | nd | + | + | + | + | nd | |
| 23 | 77/M | Skin | + | + | + | + | + | + | − | |
| 24 | 35/F | Skin | + | nd | + | + | + | + | − | |
| 25 | 80/M | Skin | + | nd | nd | + | nd | nd | nd | |
| 26 | 96/F | Skin | + | nd | + | + | + | + | + (30%) | |
| 27 | 73/M | Skin | + | nd | + | + | + | + | − | |
| 28 | 76/M | Skin | + | nd | + | + | + | + | + (50%) | |
| 29 | 54/F | Skin | + | nd | − | + | + | + | + (80%) | |
| 30 | 71/M | Skin | + | nd | + | + | + | + | − | |
| 31 | 63/M | Skin | + | nd | nd | + | + | + | + (10%) | |
| 32 | 8/M | Skin | + | + | + | + | + | + | − | |
| 33 | 64/M | Lymph node | + | nd | + | + | nd | + | + | |
| 34 | 84/M | Skin | + | + | + | + | + | + | − | |
| 35 | 60/F | Skin | + | nd | nd | + | nd | nd | nd | |
| 36 | 83/M | Skin | + | nd | nd | + | + | + | − | |
| 37 | 75/M | Skin | + | nd | + | + | + | + | − | |
| 38 | 25/M | Skin | + | nd | nd | + | + | + | − | |
| 39 | 70/F | Skin | + | nd | + | + | nd | + | − | |
| 40 | 88/F | Skin | + | + | + | + | + | + | + (10%) | |
| 41 | 72/M | Skin | + | + | + | + | + | + | − | |
| pDC proliferations associated with a myeloproliferative disorder | ||||||||||
| 42 | 52/M | Lymph node | + | + | + | (+) | + | + | − | |
| 43 | 63/F | Lymph node | + | + | + | (+) | + | (+) | − | |
| 44 | 24/M | Lymph node and skin | + | + | + | − | + | (+) | − | |
| 45 | 62/F | Lymph node | + | + | + | − | + | (+) | − | |
| 46 | 65/M | Lymph node | + | nd | + | (+) | + | + | − | |
| 47 | 71/M | Bone marrow | + | + | + | − | + | nd | − |
+ indicates all tumor cells are positive; (+), almost all tumor cells are weakly positive; +/−, most of the tumor cells are positive; Scat'rd+, scattered tumor cells are positive; −/+, most of the tumor cells are negative; –, all tumor cells are negative; nd, not done; and na, data not available.