Compatibility of simulated and observed baboon gene-marking data
| . | Probability values . | Compatible . | ||
|---|---|---|---|---|
| Criterion 1 . | Criterion 2 . | Criterion 3 . | ||
| A. Other mammalian HSC parameters | ||||
| Mouse | ||||
| R0 = 100 (HSC) | .49 | .25 | < .0001 | No |
| R0 = 300 | .31 | .06 | < .0001 | No |
| R0 = 500 | .28 | .02 | < .0001 | No |
| Cat | ||||
| R0 = 100 | .41 | .25 | .07 | Yes |
| R0 = 300 | .43 | .047 | < .0001 | No |
| R0 = 500 | .30 | .02 | < .0001 | No |
| B. Estimating replication rate, R0 = 300 | ||||
| λ = 1 replication/20 wk | .39 | .15 | .04 | No |
| λ = 1 replication/21 wk | .42 | .10 | .054 | Yes |
| λ = 1 replication/36 wk | .41 | .22 | .31 | Yes |
| λ = 1 replication/70 wk | .32 | .30 | .07 | Yes |
| λ = 1 replication/72 wk | .48 | .31 | .04 | No |
| C. Replication rate, R0 = 100 | ||||
| λ = 1 replication/6 wk | .43 | .23 | .03 | No |
| λ = 1 replication/7 wk | .5 | .24 | .054 | Yes |
| λ = 1 replication/25 wk | .29 | .30 | .057 | Yes |
| λ = 1 replication/29 wk | .24 | .31 | .04 | No |
| D. Replication rate, R0 = 500 | ||||
| λ = 1 replication/32 wk | .40 | .08 | .048 | No |
| λ = 1 replication/33 wk | .39 | .13 | .050 | Yes |
| λ = 1 replication/120 wk | .32 | .30 | .068 | Yes |
| λ = 1 replication/125 wk | .34 | .30 | .047 | No |
| E. Robustness to changes to μ | ||||
| μ = 3.0 wk | .07 | .31 | < .0001 | No |
| μ = 4.5 wk | .75 | .29 | .03 | No |
| μ = 5.0 wk | .60 | .29 | .050 | Yes |
| μ = 8.5 wk | .07 | .15 | .10 | Yes |
| μ = 9.0 wk | .046 | .16 | .07 | No |
| F. Robustness to changes to ν | ||||
| ν = 0.40 γ | .47 | .30 | .049 | No |
| ν = 0.45 γ | .41 | .30 | .08 | Yes |
| ν = 1.00 γ | .45 | .17 | .23 | Yes |
| G. Robustness to changes to γ | ||||
| γ = 0.35 λ | .61 | .29 | .04 | No |
| γ = 0.40 λ | .60 | .28 | .06 | Yes |
| γ = 1.00 λ | .38 | .23 | .46 | Yes |
| . | Probability values . | Compatible . | ||
|---|---|---|---|---|
| Criterion 1 . | Criterion 2 . | Criterion 3 . | ||
| A. Other mammalian HSC parameters | ||||
| Mouse | ||||
| R0 = 100 (HSC) | .49 | .25 | < .0001 | No |
| R0 = 300 | .31 | .06 | < .0001 | No |
| R0 = 500 | .28 | .02 | < .0001 | No |
| Cat | ||||
| R0 = 100 | .41 | .25 | .07 | Yes |
| R0 = 300 | .43 | .047 | < .0001 | No |
| R0 = 500 | .30 | .02 | < .0001 | No |
| B. Estimating replication rate, R0 = 300 | ||||
| λ = 1 replication/20 wk | .39 | .15 | .04 | No |
| λ = 1 replication/21 wk | .42 | .10 | .054 | Yes |
| λ = 1 replication/36 wk | .41 | .22 | .31 | Yes |
| λ = 1 replication/70 wk | .32 | .30 | .07 | Yes |
| λ = 1 replication/72 wk | .48 | .31 | .04 | No |
| C. Replication rate, R0 = 100 | ||||
| λ = 1 replication/6 wk | .43 | .23 | .03 | No |
| λ = 1 replication/7 wk | .5 | .24 | .054 | Yes |
| λ = 1 replication/25 wk | .29 | .30 | .057 | Yes |
| λ = 1 replication/29 wk | .24 | .31 | .04 | No |
| D. Replication rate, R0 = 500 | ||||
| λ = 1 replication/32 wk | .40 | .08 | .048 | No |
| λ = 1 replication/33 wk | .39 | .13 | .050 | Yes |
| λ = 1 replication/120 wk | .32 | .30 | .068 | Yes |
| λ = 1 replication/125 wk | .34 | .30 | .047 | No |
| E. Robustness to changes to μ | ||||
| μ = 3.0 wk | .07 | .31 | < .0001 | No |
| μ = 4.5 wk | .75 | .29 | .03 | No |
| μ = 5.0 wk | .60 | .29 | .050 | Yes |
| μ = 8.5 wk | .07 | .15 | .10 | Yes |
| μ = 9.0 wk | .046 | .16 | .07 | No |
| F. Robustness to changes to ν | ||||
| ν = 0.40 γ | .47 | .30 | .049 | No |
| ν = 0.45 γ | .41 | .30 | .08 | Yes |
| ν = 1.00 γ | .45 | .17 | .23 | Yes |
| G. Robustness to changes to γ | ||||
| γ = 0.35 λ | .61 | .29 | .04 | No |
| γ = 0.40 λ | .60 | .28 | .06 | Yes |
| γ = 1.00 λ | .38 | .23 | .46 | Yes |
Criteria 1, 2, and 3 compared the compatibility of marking percentages on the basis of the time until stabilization, the presence of drift, and the amount of variation, respectively.