Tumor spectra and incidences in Npm1+/− and Npm1+/+ mice
| Genotype/ID . | Age, mo . | Type of solid tumor . | Hematologic malignancies . |
|---|---|---|---|
| Npm1+/−, n = 16/55 (29%) | |||
| 70 | 20 | — | Myeloid leukemia |
| 36 | 24 | — | Myeloid leukemia |
| 80 | 23 | — | Myeloproliferative disease–like myeloid leukemia |
| 32D | 20 | — | Myeloid leukemia |
| 90D | 18 | Lung carcinoma | — |
| 75A | 24 | Salivary adenocarcinoma | — |
| 72D | 23 | — | T cell lymphoma/leukemia |
| B24 | 10 | — | B cell lymphoma |
| B3 | 23 | — | Myeloproliferative disease–like myeloid leukemia |
| A73 | 24 | — | Myeloid leukemia |
| A66 | 23 | Hepatocellular carcinoma | — |
| B20 | 23 | — | B cell lymphoma |
| B47 | 24 | — | Myeloproliferative disease–like myeloid leukemia |
| B22 | 24 | Lung adenocarcinoma | — |
| 3B | 24 | — | Myeloproliferative disease–like myeloid leukemia |
| 75 | 19 | — | Myeloproliferative disease–like myeloid leukemia |
| Npm1+/+, n = 3/47 (6.3%) | |||
| 85 | 21 | Cutaneous squamous cell carcinoma | — |
| A76 | 24 | Hepatocellular adenoma | — |
| 83 | 18 | Hepatocellular carcinoma | — |
| Genotype/ID . | Age, mo . | Type of solid tumor . | Hematologic malignancies . |
|---|---|---|---|
| Npm1+/−, n = 16/55 (29%) | |||
| 70 | 20 | — | Myeloid leukemia |
| 36 | 24 | — | Myeloid leukemia |
| 80 | 23 | — | Myeloproliferative disease–like myeloid leukemia |
| 32D | 20 | — | Myeloid leukemia |
| 90D | 18 | Lung carcinoma | — |
| 75A | 24 | Salivary adenocarcinoma | — |
| 72D | 23 | — | T cell lymphoma/leukemia |
| B24 | 10 | — | B cell lymphoma |
| B3 | 23 | — | Myeloproliferative disease–like myeloid leukemia |
| A73 | 24 | — | Myeloid leukemia |
| A66 | 23 | Hepatocellular carcinoma | — |
| B20 | 23 | — | B cell lymphoma |
| B47 | 24 | — | Myeloproliferative disease–like myeloid leukemia |
| B22 | 24 | Lung adenocarcinoma | — |
| 3B | 24 | — | Myeloproliferative disease–like myeloid leukemia |
| 75 | 19 | — | Myeloproliferative disease–like myeloid leukemia |
| Npm1+/+, n = 3/47 (6.3%) | |||
| 85 | 21 | Cutaneous squamous cell carcinoma | — |
| A76 | 24 | Hepatocellular adenoma | — |
| 83 | 18 | Hepatocellular carcinoma | — |
Npm1+/− versus Npm1+/+ P less than .01. The P value was calculated by chi-square test.
— indicates not applicable.