Definition of risk status
| Diagnosis and disease status . | Risk for poor outcome secondary to TRM or relapse . |
|---|---|
| ALL-CR1 | Low |
| Remission induction failure | Low |
| Philadelphia chromosome+ | Low |
| ALL-CR2 | Low |
| Length of CR 1 ≤ 18 months | High |
| ALL ≥ CR3 or relapse | High |
| AML-CR1 | Low |
| Remission induction failure | Low |
| Monosomy 7, tri 8 | High |
| 5q- | Low |
| Prior MDS | High |
| tAML | High |
| AML-CR2, any length of first CR | Low |
| Remission induction failure | Low |
| Monosomy 7, tri 8 | High |
| 5q- | Low |
| Prior MDS | High |
| tAML | High |
| AML ≥ 3CR or relapse | High |
| JMML | High |
| CML-second CP, AP, BL | High |
| Infant leukemia* | High |
| Diagnosis and disease status . | Risk for poor outcome secondary to TRM or relapse . |
|---|---|
| ALL-CR1 | Low |
| Remission induction failure | Low |
| Philadelphia chromosome+ | Low |
| ALL-CR2 | Low |
| Length of CR 1 ≤ 18 months | High |
| ALL ≥ CR3 or relapse | High |
| AML-CR1 | Low |
| Remission induction failure | Low |
| Monosomy 7, tri 8 | High |
| 5q- | Low |
| Prior MDS | High |
| tAML | High |
| AML-CR2, any length of first CR | Low |
| Remission induction failure | Low |
| Monosomy 7, tri 8 | High |
| 5q- | Low |
| Prior MDS | High |
| tAML | High |
| AML ≥ 3CR or relapse | High |
| JMML | High |
| CML-second CP, AP, BL | High |
| Infant leukemia* | High |
tAML indicates therapy-related AML.
Definition of infant leukemia is diagnosis before 6 months, or diagnosis before 1 year with MLL+ or other cytogenetic abnormalities consistent with MLL+, such as t(4;11), 11q23+, or t(9;11).