Patients failing to achieve response milestones and their subsequent therapeutic outcome
| Milestone . | Response . | Therapeutic change . | ||||||
|---|---|---|---|---|---|---|---|---|
| Already dose increased . | No dose increase . | Dose increased . | ||||||
| Off study . | Already onreduced dose . | Failed to dose increase . | ||||||
| Failed to achieve milestone . | Lost milestone . | At time of assessment . | Immediately after assessment . | |||||
| MCR 6 months | 11 (10.6%) | 2 (1.9%) | 3 | 3 | 3 | 2† | 2 | |
| CCR 9 months | 19 (18.4%) | 2 (1.9%) | 2 | 6 | 1 | 5 | 1‡ | 6 |
| < 0.01% IS by12 months | 85 (82.5%) | 5* | 5 | 8 | 4 | 10 | 18§ | 45 |
| Milestone . | Response . | Therapeutic change . | ||||||
|---|---|---|---|---|---|---|---|---|
| Already dose increased . | No dose increase . | Dose increased . | ||||||
| Off study . | Already onreduced dose . | Failed to dose increase . | ||||||
| Failed to achieve milestone . | Lost milestone . | At time of assessment . | Immediately after assessment . | |||||
| MCR 6 months | 11 (10.6%) | 2 (1.9%) | 3 | 3 | 3 | 2† | 2 | |
| CCR 9 months | 19 (18.4%) | 2 (1.9%) | 2 | 6 | 1 | 5 | 1‡ | 6 |
| < 0.01% IS by12 months | 85 (82.5%) | 5* | 5 | 8 | 4 | 10 | 18§ | 45 |
Reasons for failure to dose increase: †grade 3 cytopenia (1), unknown (1); ‡muscle cramp (1); §unknown (8), patient refusal (4), cramps (2), nausea and vomiting (2), hematemesis (1), CCF (1).
Patients demonstrated fluctuation around the level of 0.01% BCR-ABL IS.