Grade 3 or 4 toxicities in the 2-year study period
| . | Months 1-6 (n = 103) . | Months 7-12 (n = 100) . | Months 13-18 (n = 95) . | Months 19-24 (n = 88) . | ||||
|---|---|---|---|---|---|---|---|---|
| No. . | % . | No. . | % . | No. . | % . | No. . | % . | |
| Neutropenia | 21 | 20.4 | 2 | 2 | 4 | 4.2 | 0 | 0.0 |
| Thrombocytopenia | 11 | 10.7 | 4 | 4 | 2 | 2.1 | 0 | 0.0 |
| Nausea and/or vomiting | 2 | 1.9 | 0 | 0 | 1 | 1.1 | 0 | 0.0 |
| Diarrhea | 2 | 1.9 | 1 | 1 | 1 | 1.1 | 1 | 1.1 |
| Muscle cramps | 3 | 2.9 | 0 | 0 | 1 | 1.1 | 0 | 0.0 |
| Edema/fluid retention | 2 | 1.9 | 1 | 1 | 1 | 1.1 | 0 | 0.0 |
| Anemia | 8 | 7.8 | 0 | 0 | 0 | 0.0 | 2 | 2.3 |
| Rash | 5 | 4.9 | 0 | 0 | 0 | 0.0 | 0 | 0.0 |
| Fatigue | 2 | 1.9 | 0 | 0 | 0 | 0.0 | 0 | 0.0 |
| Arthralgia | 3 | 2.9 | 0 | 0 | 0 | 0.0 | 1 | 1.1 |
| Myalgia | 0 | 0.0 | 0 | 0 | 0 | 0.0 | 0 | 0.0 |
| Other | 6 | 5.8 | 2 | 2 | 2 | 2.1 | 1 | 1.1 |
| . | Months 1-6 (n = 103) . | Months 7-12 (n = 100) . | Months 13-18 (n = 95) . | Months 19-24 (n = 88) . | ||||
|---|---|---|---|---|---|---|---|---|
| No. . | % . | No. . | % . | No. . | % . | No. . | % . | |
| Neutropenia | 21 | 20.4 | 2 | 2 | 4 | 4.2 | 0 | 0.0 |
| Thrombocytopenia | 11 | 10.7 | 4 | 4 | 2 | 2.1 | 0 | 0.0 |
| Nausea and/or vomiting | 2 | 1.9 | 0 | 0 | 1 | 1.1 | 0 | 0.0 |
| Diarrhea | 2 | 1.9 | 1 | 1 | 1 | 1.1 | 1 | 1.1 |
| Muscle cramps | 3 | 2.9 | 0 | 0 | 1 | 1.1 | 0 | 0.0 |
| Edema/fluid retention | 2 | 1.9 | 1 | 1 | 1 | 1.1 | 0 | 0.0 |
| Anemia | 8 | 7.8 | 0 | 0 | 0 | 0.0 | 2 | 2.3 |
| Rash | 5 | 4.9 | 0 | 0 | 0 | 0.0 | 0 | 0.0 |
| Fatigue | 2 | 1.9 | 0 | 0 | 0 | 0.0 | 0 | 0.0 |
| Arthralgia | 3 | 2.9 | 0 | 0 | 0 | 0.0 | 1 | 1.1 |
| Myalgia | 0 | 0.0 | 0 | 0 | 0 | 0.0 | 0 | 0.0 |
| Other | 6 | 5.8 | 2 | 2 | 2 | 2.1 | 1 | 1.1 |