Comparison of cytogenetic and molecular response rates in the IRIS and TIDEL trials at 12 months and 24 months
| . | Major cytogenetic response (0%-35% Ph+) . | Complete cytogenetic response (0% Ph+) . | Major molecular response (≤ 0.1% BCR-ABL [IS]) . |
|---|---|---|---|
| Response rate at 12 months | |||
| TIDEL | 90 (85-96)* | 88 (82-94)* | 47 (37-56)* |
| IRIS | 85 (81-88)* | 69% (65-74)* | 40 (36-44)* |
| P for z test | .101 | < .001 | .214 |
| Response rate at 24 months | |||
| TIDEL | 91 (86-96)* | 90 (85-95)* | 73 (62-84)* |
| IRIS | 90 (86-93)* | 80 (76-84)* | 55 (NA) |
| P for z test | .682 | .002 | NA |
| . | Major cytogenetic response (0%-35% Ph+) . | Complete cytogenetic response (0% Ph+) . | Major molecular response (≤ 0.1% BCR-ABL [IS]) . |
|---|---|---|---|
| Response rate at 12 months | |||
| TIDEL | 90 (85-96)* | 88 (82-94)* | 47 (37-56)* |
| IRIS | 85 (81-88)* | 69% (65-74)* | 40 (36-44)* |
| P for z test | .101 | < .001 | .214 |
| Response rate at 24 months | |||
| TIDEL | 91 (86-96)* | 90 (85-95)* | 73 (62-84)* |
| IRIS | 90 (86-93)* | 80 (76-84)* | 55 (NA) |
| P for z test | .682 | .002 | NA |
IRIS figures for MCR and CCR are based on the 5-year update.13 MMR rate at 24 months in IRIS based on European Haematology Association abstract in Haematologica. 2005;90[Suppl 2]:48.
NA indicates not available.
Percentage achieving response (95% confidence intervals).