International Working Group for Myelofibrosis Research and Treatment (IWG-MRT) criteria for the diagnosis of post–polycythemia vera myelofibrosis (post-PV MF) and the distribution of meeting criteria in 68 patients with post-PV MF
| . | No. of patients (%) . |
|---|---|
| IWG-MRT required criteria | |
| 1. Previous diagnosis of polycythemia vera (WHO criteria) | 68 (100) |
| 2. Bone marrow fibrosis grade 2-3 (on 0-3 scale) | 68 (100) |
| IWG-MRT additional criteria (2 are required) | |
| 1. Anemia* or | 43 (63) |
| Sustained loss of requirement of phlebotomy or cytoreduction | 25 (37) |
| 2. Leukoerythroblastic peripheral blood picture | 68 (100) |
| 3. Increasing splenomegaly | 66/67 (98)‡ |
| Palpable spleen more than 5 cm from left costal margin | 54 (82) |
| Appearance of a newly palpable splenomegaly | 12 (18) |
| 4. Development of more than 1 of the constitutional symptoms† | 26 (38) |
| . | No. of patients (%) . |
|---|---|
| IWG-MRT required criteria | |
| 1. Previous diagnosis of polycythemia vera (WHO criteria) | 68 (100) |
| 2. Bone marrow fibrosis grade 2-3 (on 0-3 scale) | 68 (100) |
| IWG-MRT additional criteria (2 are required) | |
| 1. Anemia* or | 43 (63) |
| Sustained loss of requirement of phlebotomy or cytoreduction | 25 (37) |
| 2. Leukoerythroblastic peripheral blood picture | 68 (100) |
| 3. Increasing splenomegaly | 66/67 (98)‡ |
| Palpable spleen more than 5 cm from left costal margin | 54 (82) |
| Appearance of a newly palpable splenomegaly | 12 (18) |
| 4. Development of more than 1 of the constitutional symptoms† | 26 (38) |
Defined as hemoglobin value less than 120 g/L (12 g/dL) for female and less than 135 g/L (13.5 g/dL) for male.
Defined as 10% or more weight loss in 6 months, night sweats, unexplained fever (>37.5°C).
One patient underwent splenectomy before diagnosis, so the calculation was provided on 67 patients.