Table 1 Demographic and hematologic... | American Society of Hematology

Table 1

Demographic and hematologic characteristics at diagnosis of 68 patients with post–polycythemia vera myelofibrosis

Characteristic	No.
No. of patients	68
Age at diagnosis, y† (range)	65 (44-81)
Male/female	45/23
WBC count, × 10⁹/L,† (range)	12.2 (2.3-98)
Hemoglobin level, g/L,† (range)	123 (78-148)
PLT count, × 10⁹/L,† (range)	369 (50-1827)
Spleen size, cm below left costal margin	7 (0-25)
Bone marrow findings
Marrow cellularity,† % (range)	90 (70-100)
Reticulin fibrosis, grade 2:grade 3	3:1
MK cluster, loose:dense	0.6:1
Marrow myeloblast,† % (range)	0 (0-5)
Lactate dehydrogenase, U/L,† (range), n = 41	837 (460-3151)
Circulating CD34⁺ cells/μL,† (range), n = 39	44.3 (12.1-1005)
No. JAK2 (V617F) positive, (%), n = 27	27 (100)
Proportion of JAK2 (V617F) alleles,† % (range)	87 (10-100)
*Bone marrow karyotype (%)
Favorable	20 (80)
Unfavorable	5 (20)

Characteristic	No.
No. of patients	68
Age at diagnosis, y† (range)	65 (44-81)
Male/female	45/23
WBC count, × 10⁹/L,† (range)	12.2 (2.3-98)
Hemoglobin level, g/L,† (range)	123 (78-148)
PLT count, × 10⁹/L,† (range)	369 (50-1827)
Spleen size, cm below left costal margin	7 (0-25)
Bone marrow findings
Marrow cellularity,† % (range)	90 (70-100)
Reticulin fibrosis, grade 2:grade 3	3:1
MK cluster, loose:dense	0.6:1
Marrow myeloblast,† % (range)	0 (0-5)
Lactate dehydrogenase, U/L,† (range), n = 41	837 (460-3151)
Circulating CD34⁺ cells/μL,† (range), n = 39	44.3 (12.1-1005)
No. JAK2 (V617F) positive, (%), n = 27	27 (100)
Proportion of JAK2 (V617F) alleles,† % (range)	87 (10-100)
*Bone marrow karyotype (%)
Favorable	20 (80)
Unfavorable	5 (20)

Normal range of circulating CD34⁺ cells: less than 10/μL; normal range of LDH: less than 450 mU/mL.

Favorable indicates normal, 20q−; 13q−²³; unfavorable, other than favorable.

Data are medians.