Clinicobiologic characteristics of the patients
Patient ID no. . | Disease status . | IgVH mutational status . | ZAP-70 . | del13q14, % . | del17p13, % . | Trisomy 12, % . | del11q23, % . | miRNA profile . | |
---|---|---|---|---|---|---|---|---|---|
Cloning . | qRT-PCR . | ||||||||
1 | Stable | Mutated | − | NE | NE | NE | NE | − | + |
2 | Stable | Mutated | NE | NE | NE | NE | NE | + | + |
3 | Progr | Mutated | − | Neg | Neg | Neg | Neg | − | + |
4 | Progr | Germline | + | Neg | Neg | Neg | Neg | + | + |
5 | ND | Germline | + | 86 | Neg | Neg | 81 | − | + |
6 | Progr | Germline | + | Neg | Neg | Neg | Neg | − | + |
7 | Progr | Germline | − | NE | NE | NE | NE | − | + |
8 | Progr | Germline | + | 94 | Neg | Neg | Neg | + | + |
9 | Stable | Mutated | + | Neg | Neg | Neg | Neg | + | + |
10 | ND | Germline | − | NE | NE | NE | NE | − | + |
11 | Stable | NE | − | NE | NE | NE | NE | − | + |
12 | Progr | Germline | + | 87 | Neg | Neg | Neg | − | + |
13 | Stable | Mutated | + | 11 | Neg | Neg | Neg | − | + |
14 | Stable | Mutated | NE | NE | NE | NE | NE | + | − |
15 | Progr | Germline | + | 40 | Neg | Neg | 48 | − | + |
16 | Progr | Germline | + | Neg | Neg | Neg | Neg | + | − |
17 | Stable | Mutated | − | Pos | Neg | Neg | Neg | + | − |
18 | ND | NE | NE | NE | NE | NE | NE | + | − |
19 | Progr | Mutated | − | 82 | Neg | Neg | Neg | − | + |
20 | ND | Mutated | NE | NE | NE | NE | NE | + | − |
21 | ND | Germline | + | NE | NE | NE | NE | − | + |
22 | ND | Mutated | + | Neg | 8 | Neg | Neg | − | + |
23 | ND | Germline | + | Neg | Neg | Neg | 61 | − | + |
24 | Progr | Germline | + | NE | NE | NE | NE | − | + |
26 | Stable | Mutated | − | 56 | 21 | Neg | 18 | − | + |
27 | ND | Mutated | − | 81 | Neg | Neg | Neg | − | + |
28 | Stable | Mutated | − | 41 | Neg | Neg | Neg | − | + |
30 | Stable | Mutated | − | Neg | Neg | Neg | Neg | − | + |
32 | Progr | Mutated | + | 99 | Neg | Neg | Neg | − | + |
35 | Stable | Mutated | − | 19 | Neg | Neg | Neg | − | + |
36 | ND | Mutated | − | Neg | NE | NE | NE | − | + |
37 | ND | Mutated | + | 74 homozygosis | Neg | Neg | Neg | − | + |
43 | Progr | Germline | + | Neg | Neg | Neg | Neg | − | + |
50 | Stable | Mutated | NE | NE | NE | NE | NE | − | + |
57 | ND | Germline | − | 78 | Neg | Neg | Neg | − | + |
58 | ND | Mutated | − | 72 | Neg | Neg | Neg | − | + |
59 | Progr | Mutated | − | 49 | Neg | Neg | Neg | − | + |
60 | ND | Mutated | − | 89 | Neg | Neg | Neg | − | + |
61 | Progr | Mutated | + | Neg | Neg | Neg | Neg | − | + |
62 | ND | Germline | − | Neg | Neg | 51 | Neg | − | + |
45 | Progr | Mutated | − | 50 | Neg | Neg | Neg | − | + |
64 | Progr | Germline | + | Neg | Neg | 75 | Neg | − | + |
65 | Progr | Germline | + | Neg | 8 | Neg | 95 | − | + |
66 | Progr | Mutated | − | 95 | Neg | Neg | Neg | − | + |
67 | Progr | Mutated | − | 89 | Neg | 74 | Neg | − | + |
68 | ND | Mutated | − | 63 homozygosis | Neg | Neg | Neg | − | + |
69 | Progr | Mutated | + | 84 | Neg | 60 | Neg | − | + |
70 | Progr | Germline | + | 80 | Neg | Neg | 95 | − | + |
71 | Progr | Germline | + | Neg | Neg | Neg | Neg | − | + |
72 | Stable | Mutated | − | Neg | 14 | Neg | Neg | − | + |
73 | Progr | Germline | + | Neg | Neg | Neg | 20 | − | + |
74 | Progr | Germline | + | Neg | 94 | Neg | Neg | − | + |
75 | Progr | Mutated | + | Neg | Neg | Neg | 6 | − | + |
76 | Progr | Mutated | − | 85 homozygosis | Neg | 74 | Neg | − | + |
77 | Progr | Germline | − | 85 | 8 | Neg | 19 | − | + |
78 | Progr | Germline | + | 89 | Neg | Neg | Neg | − | + |
Patient ID no. . | Disease status . | IgVH mutational status . | ZAP-70 . | del13q14, % . | del17p13, % . | Trisomy 12, % . | del11q23, % . | miRNA profile . | |
---|---|---|---|---|---|---|---|---|---|
Cloning . | qRT-PCR . | ||||||||
1 | Stable | Mutated | − | NE | NE | NE | NE | − | + |
2 | Stable | Mutated | NE | NE | NE | NE | NE | + | + |
3 | Progr | Mutated | − | Neg | Neg | Neg | Neg | − | + |
4 | Progr | Germline | + | Neg | Neg | Neg | Neg | + | + |
5 | ND | Germline | + | 86 | Neg | Neg | 81 | − | + |
6 | Progr | Germline | + | Neg | Neg | Neg | Neg | − | + |
7 | Progr | Germline | − | NE | NE | NE | NE | − | + |
8 | Progr | Germline | + | 94 | Neg | Neg | Neg | + | + |
9 | Stable | Mutated | + | Neg | Neg | Neg | Neg | + | + |
10 | ND | Germline | − | NE | NE | NE | NE | − | + |
11 | Stable | NE | − | NE | NE | NE | NE | − | + |
12 | Progr | Germline | + | 87 | Neg | Neg | Neg | − | + |
13 | Stable | Mutated | + | 11 | Neg | Neg | Neg | − | + |
14 | Stable | Mutated | NE | NE | NE | NE | NE | + | − |
15 | Progr | Germline | + | 40 | Neg | Neg | 48 | − | + |
16 | Progr | Germline | + | Neg | Neg | Neg | Neg | + | − |
17 | Stable | Mutated | − | Pos | Neg | Neg | Neg | + | − |
18 | ND | NE | NE | NE | NE | NE | NE | + | − |
19 | Progr | Mutated | − | 82 | Neg | Neg | Neg | − | + |
20 | ND | Mutated | NE | NE | NE | NE | NE | + | − |
21 | ND | Germline | + | NE | NE | NE | NE | − | + |
22 | ND | Mutated | + | Neg | 8 | Neg | Neg | − | + |
23 | ND | Germline | + | Neg | Neg | Neg | 61 | − | + |
24 | Progr | Germline | + | NE | NE | NE | NE | − | + |
26 | Stable | Mutated | − | 56 | 21 | Neg | 18 | − | + |
27 | ND | Mutated | − | 81 | Neg | Neg | Neg | − | + |
28 | Stable | Mutated | − | 41 | Neg | Neg | Neg | − | + |
30 | Stable | Mutated | − | Neg | Neg | Neg | Neg | − | + |
32 | Progr | Mutated | + | 99 | Neg | Neg | Neg | − | + |
35 | Stable | Mutated | − | 19 | Neg | Neg | Neg | − | + |
36 | ND | Mutated | − | Neg | NE | NE | NE | − | + |
37 | ND | Mutated | + | 74 homozygosis | Neg | Neg | Neg | − | + |
43 | Progr | Germline | + | Neg | Neg | Neg | Neg | − | + |
50 | Stable | Mutated | NE | NE | NE | NE | NE | − | + |
57 | ND | Germline | − | 78 | Neg | Neg | Neg | − | + |
58 | ND | Mutated | − | 72 | Neg | Neg | Neg | − | + |
59 | Progr | Mutated | − | 49 | Neg | Neg | Neg | − | + |
60 | ND | Mutated | − | 89 | Neg | Neg | Neg | − | + |
61 | Progr | Mutated | + | Neg | Neg | Neg | Neg | − | + |
62 | ND | Germline | − | Neg | Neg | 51 | Neg | − | + |
45 | Progr | Mutated | − | 50 | Neg | Neg | Neg | − | + |
64 | Progr | Germline | + | Neg | Neg | 75 | Neg | − | + |
65 | Progr | Germline | + | Neg | 8 | Neg | 95 | − | + |
66 | Progr | Mutated | − | 95 | Neg | Neg | Neg | − | + |
67 | Progr | Mutated | − | 89 | Neg | 74 | Neg | − | + |
68 | ND | Mutated | − | 63 homozygosis | Neg | Neg | Neg | − | + |
69 | Progr | Mutated | + | 84 | Neg | 60 | Neg | − | + |
70 | Progr | Germline | + | 80 | Neg | Neg | 95 | − | + |
71 | Progr | Germline | + | Neg | Neg | Neg | Neg | − | + |
72 | Stable | Mutated | − | Neg | 14 | Neg | Neg | − | + |
73 | Progr | Germline | + | Neg | Neg | Neg | 20 | − | + |
74 | Progr | Germline | + | Neg | 94 | Neg | Neg | − | + |
75 | Progr | Mutated | + | Neg | Neg | Neg | 6 | − | + |
76 | Progr | Mutated | − | 85 homozygosis | Neg | 74 | Neg | − | + |
77 | Progr | Germline | − | 85 | 8 | Neg | 19 | − | + |
78 | Progr | Germline | + | 89 | Neg | Neg | Neg | − | + |
NE indicates not evaluated; Progr, progressive; Neg, negative; ND, not defined.