Comparison of prognostic factors in terms of time to first treatment and overall survival
| Parameter . | Time to first treatment . | Overall survival . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| n . | Median, y . | HR . | P . | 95% CI . | Median, y . | HR . | P . | 95% CI . | |
| VH status | 2.9 | < .001 | 3.2-9.6 | 3.1 | < .001 | 2.8-9.3 | |||
| Less than 98% | 126 | 11.2 | 13.7 | ||||||
| 98% or more | 59 | 0.6 | 5.9 | ||||||
| CD38 | 2.8 | < .001 | 2.1-4.8 | 2.9 | < .001 | 1.9-4.6 | |||
| Less than 20% | 94 | 16.5 | Undefined | ||||||
| 20% or more | 91 | 1.8 | 8.0 | ||||||
| ZAP-70 | 1.6 | .01 | 1.1-2.6 | 2.1 | < .001 | 1.4-3.5 | |||
| Less than 20% | 101 | 12.0 | 15.8 | ||||||
| 20% or more | 84 | 3.0 | 8.0 | ||||||
| Bcl-2 | 1.6 | .02 | 1.1-2.5 | 1.7 | .01 | 1.1-2.7 | |||
| Less than 16 284 | 89 | 9.3 | 19.0 | ||||||
| 16 284 or more | 96 | 3.0 | 8.7 | ||||||
| Bax | 1.6 | .01 | 1.2-2.6 | 1.6 | .05 | 0.9-2.5 | |||
| 1538 or more | 93 | 11.6 | 12.0 | ||||||
| Less than 1538 | 92 | 1.8 | 8.7 | ||||||
| Mcl-1 | 2.1 | < .001 | 1.5-3.4 | 1.8 | .008 | 1.2-2.9 | |||
| Less than 1508 | 93 | 9.3 | 13.8 | ||||||
| 1508 or more | 92 | 1.4 | 8.6 | ||||||
| Bcl-2/Bax | 2.0 | < .001 | 1.4-3.3 | 2.1 | < .001 | 1.4-3.4 | |||
| Less than 10.4 | 96 | 14.7 | 20.4 | ||||||
| 10.4 or more | 89 | 1.9 | 8.6 | ||||||
| Mcl-1/Bax | 3.2 | < .001 | 2.1-4.7 | 2.4 | < .001 | 1.5-3.6 | |||
| Less than 0.9 | 97 | 14.7 | 19.0 | ||||||
| 0.9 or more | 88 | 1.5 | 8.4 | ||||||
| Parameter . | Time to first treatment . | Overall survival . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| n . | Median, y . | HR . | P . | 95% CI . | Median, y . | HR . | P . | 95% CI . | |
| VH status | 2.9 | < .001 | 3.2-9.6 | 3.1 | < .001 | 2.8-9.3 | |||
| Less than 98% | 126 | 11.2 | 13.7 | ||||||
| 98% or more | 59 | 0.6 | 5.9 | ||||||
| CD38 | 2.8 | < .001 | 2.1-4.8 | 2.9 | < .001 | 1.9-4.6 | |||
| Less than 20% | 94 | 16.5 | Undefined | ||||||
| 20% or more | 91 | 1.8 | 8.0 | ||||||
| ZAP-70 | 1.6 | .01 | 1.1-2.6 | 2.1 | < .001 | 1.4-3.5 | |||
| Less than 20% | 101 | 12.0 | 15.8 | ||||||
| 20% or more | 84 | 3.0 | 8.0 | ||||||
| Bcl-2 | 1.6 | .02 | 1.1-2.5 | 1.7 | .01 | 1.1-2.7 | |||
| Less than 16 284 | 89 | 9.3 | 19.0 | ||||||
| 16 284 or more | 96 | 3.0 | 8.7 | ||||||
| Bax | 1.6 | .01 | 1.2-2.6 | 1.6 | .05 | 0.9-2.5 | |||
| 1538 or more | 93 | 11.6 | 12.0 | ||||||
| Less than 1538 | 92 | 1.8 | 8.7 | ||||||
| Mcl-1 | 2.1 | < .001 | 1.5-3.4 | 1.8 | .008 | 1.2-2.9 | |||
| Less than 1508 | 93 | 9.3 | 13.8 | ||||||
| 1508 or more | 92 | 1.4 | 8.6 | ||||||
| Bcl-2/Bax | 2.0 | < .001 | 1.4-3.3 | 2.1 | < .001 | 1.4-3.4 | |||
| Less than 10.4 | 96 | 14.7 | 20.4 | ||||||
| 10.4 or more | 89 | 1.9 | 8.6 | ||||||
| Mcl-1/Bax | 3.2 | < .001 | 2.1-4.7 | 2.4 | < .001 | 1.5-3.6 | |||
| Less than 0.9 | 97 | 14.7 | 19.0 | ||||||
| 0.9 or more | 88 | 1.5 | 8.4 | ||||||
HR indicates hazard ratio; and CI, confidence interval.