Infections after HDIT for SSc
| Infections . | Frequency, no. . | Site . | |
|---|---|---|---|
| Less than 3 mo . | More than 3 mo . | ||
| Virus | |||
| EBV-associated PTLD | 1 | 0 | Systemic |
| Herpes simplex | 3 | 0 | Perianal, vaginal, oral |
| Cytomegalovirus | |||
| Reactivation* | 6 | 0 | Blood |
| Disease | 1 | 0 | Gastrointestinal tract |
| Varicella zoster† | 1 | 5 | Skin |
| BK virus | 1 | 0 | Hemorrhagic cystitis |
| Bacteria | |||
| Bacteremia | 11 | 0 | |
| Urinary tract infection | 3 | 0 | Bladder |
| Exit site infections | 3 | 0 | Central line, 2; J tube, 1 |
| Osteomyelitis‡ | 1 | 0 | Elbow |
| Cellulitis‡ | 1 | 0 | Thumb |
| Aspiration pneumonia§ | 1 | 3 | Lung |
| Fungus: Aspergillus flavus | 1 | 0 | Isolated skin (1 site) |
| Infections . | Frequency, no. . | Site . | |
|---|---|---|---|
| Less than 3 mo . | More than 3 mo . | ||
| Virus | |||
| EBV-associated PTLD | 1 | 0 | Systemic |
| Herpes simplex | 3 | 0 | Perianal, vaginal, oral |
| Cytomegalovirus | |||
| Reactivation* | 6 | 0 | Blood |
| Disease | 1 | 0 | Gastrointestinal tract |
| Varicella zoster† | 1 | 5 | Skin |
| BK virus | 1 | 0 | Hemorrhagic cystitis |
| Bacteria | |||
| Bacteremia | 11 | 0 | |
| Urinary tract infection | 3 | 0 | Bladder |
| Exit site infections | 3 | 0 | Central line, 2; J tube, 1 |
| Osteomyelitis‡ | 1 | 0 | Elbow |
| Cellulitis‡ | 1 | 0 | Thumb |
| Aspiration pneumonia§ | 1 | 3 | Lung |
| Fungus: Aspergillus flavus | 1 | 0 | Isolated skin (1 site) |
Infectious events were ascertained until 2 years (or longer for VZV infections) after HDIT and autologous HCT.
Cytomeglovirus reactivation was treated preemptively with antiviral therapy.
Varicella zoster reactivation in patients not receiving antiviral prophylaxis.
Secondary to skin ulcer related to SSc.
Late aspiration pneumonia events were attributed to abnormal esophageal function and gastric reflux associated with systemic sclerosis.