Treatment response in groups of prognostic interest
| Subpopulations . | Patients with MCyR . | Patients with CCyR . | ||||||
|---|---|---|---|---|---|---|---|---|
| Dasatinib . | High-dose imatinib . | Dasatinib . | High-dose imatinib . | |||||
| n/N (%) . | 95% CI . | n/N (%) . | 95% CI . | n/N (%) . | 95% CI . | n/N (%) . | 95% CI . | |
| Prior chemotherapy | 15/39 (38) | 23.4-55.4 | 4/18 (22) | 6.4-47.6 | 12/39 (31) | 17.0-47.6 | 1/18 (6) | 0.1-27.3 |
| Prior stem cell transplant | 3/7 (43) | 9.9-81.6 | 1/2 (50) | 1.3-98.7 | 3/7 (43) | 9.9-81.6 | 0/2 | 0.0-84.2 |
| Imatinib 600 mg/day | 31/63 (49) | 36.4-62.1* | 8/34 (24) | 10.7-41.2 | 24/63 (38) | 26.1-51.2‡ | 2/34 (6) | 0.7-19.7 |
| No prior CHR with imatinib | 4/8 (50) | 15.7-84.3 | 1/2 (50) | 1.3-98.7 | 3/8 (38) | 8.5-75.5 | 1/2 (50) | 1.3-98.7 |
| No prior CyR with imatinib | 19/39 (49) | 32.4-65.2† | 1/15 (7) | 0.2-31.9 | 12/39 (31) | 17.0-47.6 | 1/15 (7) | 0.2-31.9 |
| BCR-ABL mutation | 19/41 (46) | 30.7-62.6 | 3/11 (27) | 6.0-61.0 | 13/41 (32) | 18.1-48.1 | 2/11 (18) | 2.3-51.8 |
| Subpopulations . | Patients with MCyR . | Patients with CCyR . | ||||||
|---|---|---|---|---|---|---|---|---|
| Dasatinib . | High-dose imatinib . | Dasatinib . | High-dose imatinib . | |||||
| n/N (%) . | 95% CI . | n/N (%) . | 95% CI . | n/N (%) . | 95% CI . | n/N (%) . | 95% CI . | |
| Prior chemotherapy | 15/39 (38) | 23.4-55.4 | 4/18 (22) | 6.4-47.6 | 12/39 (31) | 17.0-47.6 | 1/18 (6) | 0.1-27.3 |
| Prior stem cell transplant | 3/7 (43) | 9.9-81.6 | 1/2 (50) | 1.3-98.7 | 3/7 (43) | 9.9-81.6 | 0/2 | 0.0-84.2 |
| Imatinib 600 mg/day | 31/63 (49) | 36.4-62.1* | 8/34 (24) | 10.7-41.2 | 24/63 (38) | 26.1-51.2‡ | 2/34 (6) | 0.7-19.7 |
| No prior CHR with imatinib | 4/8 (50) | 15.7-84.3 | 1/2 (50) | 1.3-98.7 | 3/8 (38) | 8.5-75.5 | 1/2 (50) | 1.3-98.7 |
| No prior CyR with imatinib | 19/39 (49) | 32.4-65.2† | 1/15 (7) | 0.2-31.9 | 12/39 (31) | 17.0-47.6 | 1/15 (7) | 0.2-31.9 |
| BCR-ABL mutation | 19/41 (46) | 30.7-62.6 | 3/11 (27) | 6.0-61.0 | 13/41 (32) | 18.1-48.1 | 2/11 (18) | 2.3-51.8 |
CCyR indicates complete cytogenetic response; CHR, complete hematologic response; CI, confidence interval; CyR, cytogenetic response; MCyR, major cytogenetic response; n/N, numbers of patients with a response/number of patients treated.
Statistically significant differences between treatments:
P = .015;
P = .006;
P = .0006.