Causes of death
| . | No. of patients (%) . | |
|---|---|---|
| Secondary MDS/tAML . | De novo MDS/tAML . | |
| Relapse | 65 (40) | 67 (33) |
| Infections | 31 (18) | 39 (19) |
| Invasive fungal | 18 (10) | 17 (8) |
| Bacterial | 7 (4) | 14 (7) |
| CMV pneumonia | 4 (2) | 5 (3) |
| Other viruses | 2 (1) | 3 (2) |
| Organ failure | 42 (24) | 53 (26) |
| MOF | 14 (8) | 21 (10) |
| Respiratory failure | 16 (9) | 17 (8) |
| SOS/hepatic failure | 7 (4) | 9 (5) |
| Cardiac disease | 3 (2) | 5 (3) |
| Renal failure | 2 (1) | 1 (1) |
| GVHD | ||
| Acute | 15 (9) | 24 (2) |
| Chronic | 2 (1) | 5 (3) |
| Other | 21 (12) | 14 (7) |
| Graft failure | 2 (1) | 4 (2) |
| Secondary cancer | — | 2 (1) |
| Relapse of original disease | 9 (5) | — |
| Miscellaneous | 10 (6) | 8 (4) |
| Total | 176 | 202 |
| . | No. of patients (%) . | |
|---|---|---|
| Secondary MDS/tAML . | De novo MDS/tAML . | |
| Relapse | 65 (40) | 67 (33) |
| Infections | 31 (18) | 39 (19) |
| Invasive fungal | 18 (10) | 17 (8) |
| Bacterial | 7 (4) | 14 (7) |
| CMV pneumonia | 4 (2) | 5 (3) |
| Other viruses | 2 (1) | 3 (2) |
| Organ failure | 42 (24) | 53 (26) |
| MOF | 14 (8) | 21 (10) |
| Respiratory failure | 16 (9) | 17 (8) |
| SOS/hepatic failure | 7 (4) | 9 (5) |
| Cardiac disease | 3 (2) | 5 (3) |
| Renal failure | 2 (1) | 1 (1) |
| GVHD | ||
| Acute | 15 (9) | 24 (2) |
| Chronic | 2 (1) | 5 (3) |
| Other | 21 (12) | 14 (7) |
| Graft failure | 2 (1) | 4 (2) |
| Secondary cancer | — | 2 (1) |
| Relapse of original disease | 9 (5) | — |
| Miscellaneous | 10 (6) | 8 (4) |
| Total | 176 | 202 |
CMV indicates cytomegalovirus; MOF, multiorgan failure; SOS, sinusoidal obstruction syndrome; GVHD, graft-versus-host disease; and —, not applicable.