Probe sets identifying independent predictors of relapse in childhood ALL
| Probe set Id . | Gene name . | Gene symbol . | Biologic process . | P* . |
|---|---|---|---|---|
| 201291_s_at | Topoisomerase (DNA) II alpha 170kDa | TOP2A | DNA replication, DNA topologic change, DNA repair | .014 |
| 203022_at | Ribonuclease H2, large subunit | RNASEH2A | DNA replication, RNA catabolism, RNA metabolism | .032 |
| 204441_s_at | Polymerase (DNA directed), alpha 2 (70-kDa subunit) | POLA2 | DNA replication | .016 |
| 201897_s_at | CDC28 protein kinase regulatory subunit 1B | CKS1B | Cell cycle | < .001 |
| 202705_at | Cyclin B2 | CCNB2 | Cell cycle | .010 |
| 203214_x_at | Cell division cycle 2, G1 to S and G2 to M | CDC2 | Cell cycle | .016 |
| 203362_s_at | MAD2 mitotic arrest deficient-like 1 (yeast) | MAD2L1 | Cell cycle | .010 |
| 212949_at | Barren homolog 1 (Drosophila) | BRRN1 | Cell cycle | .021 |
| 204334_at | Kruppel-like factor 7 (ubiquitous) | KLF7 | Cell cycle, transcription | .015 |
| 201457_x_at | BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) | BUB3 | Mitosis | < .001 |
| 218039_at | Nucleolar and spindle associated protein 1 | NUSAP1 | Mitosis | .022 |
| 200853_at | H2A histone family, member Z | H2AFZ | Nucleosome assembly, chromosome organization | < .001 |
| 213911_s_at | H2A histone family, member Z | H2AFZ | .004 | |
| 204603_at | Exonuclease 1 | EXO1 | DNA repair | .004 |
| 219650_at | FLJ20105 protein | FLJ20105 | Unknown | < .001 |
| Probe set Id . | Gene name . | Gene symbol . | Biologic process . | P* . |
|---|---|---|---|---|
| 201291_s_at | Topoisomerase (DNA) II alpha 170kDa | TOP2A | DNA replication, DNA topologic change, DNA repair | .014 |
| 203022_at | Ribonuclease H2, large subunit | RNASEH2A | DNA replication, RNA catabolism, RNA metabolism | .032 |
| 204441_s_at | Polymerase (DNA directed), alpha 2 (70-kDa subunit) | POLA2 | DNA replication | .016 |
| 201897_s_at | CDC28 protein kinase regulatory subunit 1B | CKS1B | Cell cycle | < .001 |
| 202705_at | Cyclin B2 | CCNB2 | Cell cycle | .010 |
| 203214_x_at | Cell division cycle 2, G1 to S and G2 to M | CDC2 | Cell cycle | .016 |
| 203362_s_at | MAD2 mitotic arrest deficient-like 1 (yeast) | MAD2L1 | Cell cycle | .010 |
| 212949_at | Barren homolog 1 (Drosophila) | BRRN1 | Cell cycle | .021 |
| 204334_at | Kruppel-like factor 7 (ubiquitous) | KLF7 | Cell cycle, transcription | .015 |
| 201457_x_at | BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) | BUB3 | Mitosis | < .001 |
| 218039_at | Nucleolar and spindle associated protein 1 | NUSAP1 | Mitosis | .022 |
| 200853_at | H2A histone family, member Z | H2AFZ | Nucleosome assembly, chromosome organization | < .001 |
| 213911_s_at | H2A histone family, member Z | H2AFZ | .004 | |
| 204603_at | Exonuclease 1 | EXO1 | DNA repair | .004 |
| 219650_at | FLJ20105 protein | FLJ20105 | Unknown | < .001 |
Association with cumulative incidence of relapse by Fine and Gray method. The expression of each gene was treated as a continuous variable and adjusted for age, leukocyte count at diagnosis, and genetic subtype.