Clinical and demographic characteristics of 1107 non-APL AML patients in the total cohort
| . | Total no. . | FLT3/TKD− (% of total TKD−) . | FLT3/TKD+ (% of total TKD+) . | Percent FLT3/TKD+ . | P . | Percent FLT3/ITD+ . |
|---|---|---|---|---|---|---|
| Total | 1107 | 980 | 127 | 11 | .3 | 26 |
| AML10 | 380 | 331 (34) | 49 (39) | 13 | N/A | 23 |
| AML12 | 727 | 649 (66) | 78 (61) | 11 | N/A | 27 |
| Type of AML | .02 | |||||
| De novo | 1024 | 900 (92) | 124 (98) | 12 | N/A | 26 |
| Secondary | 83 | 80 (8) | 3 (2) | 4 | N/A | 23 |
| FAB type | .02 | |||||
| M0 | 38 | 35 (4) | 3 (3) | 8 | N/A | 8 |
| M1 | 215 | 196 (21) | 19 (16) | 9 | N/A | 29 |
| M2 | 323 | 295 (32) | 28 (23) | 9 | N/A | 24 |
| M4 | 277 | 231 (25) | 46 (38) | 17 | N/A | 30 |
| M5 | 130 | 112 (12) | 18 (15) | 14 | N/A | 32 |
| M6 | 30 | 24 (3) | 6 (5) | 20 | N/A | 7 |
| M7 | 15 | 15 (2) | 0 | 0 | N/A | 7 |
| RAEB-t | 19 | 19 (2) | 0 | 0 | N/A | 5 |
| Bilineage | 1 | 1 (<.5) | 0 | 0 | N/A | 100 |
| Unknown | 59 | 52 | 7 | 12 | N/A | 19 |
| Sex | .07 | |||||
| Female | 570 | 495 (51) | 75 (59) | 13 | N/A | 27 |
| Male | 537 | 485 (49) | 52 (41) | 10 | N/A | 25 |
| Performance status | .3 | |||||
| 0 | 445 | 398 (41) | 47 (37) | 11 | N/A | 27 |
| 1 | 285 | 253 (26) | 32 (25) | 11 | N/A | 23 |
| 2 | 259 | 227 (23) | 32 (25) | 12 | N/A | 25 |
| 3 | 102 | 89 (9) | 13 (10) | 13 | N/A | 27 |
| 4 | 16 | 13 (1) | 3 (2) | 19 | N/A | 25 |
| Age, y | .6 | |||||
| 15-29 | 216 | 192 (20) | 24 (19) | 11 | N/A | 21 |
| 30-39 | 242 | 220 (22) | 22 (17) | 9 | N/A | 24 |
| 40-49 | 317 | 272 (28) | 45 (35) | 14 | N/A | 28 |
| 50-59 | 305 | 273 (28) | 32 (25) | 10 | N/A | 27 |
| 60 or older | 27 | 23 (2) | 4 (3) | 15 | N/A | 41 |
| Median | 42 | 42 | 43 | N/A | N/A | N/A |
| WBC, × 109/L | .006 | |||||
| Less than 10 | 317 | 292 (30) | 25 (20) | 8 | N/A | 10 |
| 10-19.9 | 173 | 156 (16) | 17 (13) | 10 | N/A | 23 |
| 20-49.9 | 252 | 220 (23) | 32 (25) | 13 | N/A | 27 |
| 50-99.9 | 173 | 144 (15) | 29 (23) | 17 | N/A | 35 |
| 100 or above | 171 | 148 (15) | 23 (18) | 13 | N/A | 47 |
| Unknown | 21 | 20 | 1 | 5 | N/A | 19 |
| Median | 24.5 | 23 | 38.3 | N/A | N/A | N/A |
| . | Total no. . | FLT3/TKD− (% of total TKD−) . | FLT3/TKD+ (% of total TKD+) . | Percent FLT3/TKD+ . | P . | Percent FLT3/ITD+ . |
|---|---|---|---|---|---|---|
| Total | 1107 | 980 | 127 | 11 | .3 | 26 |
| AML10 | 380 | 331 (34) | 49 (39) | 13 | N/A | 23 |
| AML12 | 727 | 649 (66) | 78 (61) | 11 | N/A | 27 |
| Type of AML | .02 | |||||
| De novo | 1024 | 900 (92) | 124 (98) | 12 | N/A | 26 |
| Secondary | 83 | 80 (8) | 3 (2) | 4 | N/A | 23 |
| FAB type | .02 | |||||
| M0 | 38 | 35 (4) | 3 (3) | 8 | N/A | 8 |
| M1 | 215 | 196 (21) | 19 (16) | 9 | N/A | 29 |
| M2 | 323 | 295 (32) | 28 (23) | 9 | N/A | 24 |
| M4 | 277 | 231 (25) | 46 (38) | 17 | N/A | 30 |
| M5 | 130 | 112 (12) | 18 (15) | 14 | N/A | 32 |
| M6 | 30 | 24 (3) | 6 (5) | 20 | N/A | 7 |
| M7 | 15 | 15 (2) | 0 | 0 | N/A | 7 |
| RAEB-t | 19 | 19 (2) | 0 | 0 | N/A | 5 |
| Bilineage | 1 | 1 (<.5) | 0 | 0 | N/A | 100 |
| Unknown | 59 | 52 | 7 | 12 | N/A | 19 |
| Sex | .07 | |||||
| Female | 570 | 495 (51) | 75 (59) | 13 | N/A | 27 |
| Male | 537 | 485 (49) | 52 (41) | 10 | N/A | 25 |
| Performance status | .3 | |||||
| 0 | 445 | 398 (41) | 47 (37) | 11 | N/A | 27 |
| 1 | 285 | 253 (26) | 32 (25) | 11 | N/A | 23 |
| 2 | 259 | 227 (23) | 32 (25) | 12 | N/A | 25 |
| 3 | 102 | 89 (9) | 13 (10) | 13 | N/A | 27 |
| 4 | 16 | 13 (1) | 3 (2) | 19 | N/A | 25 |
| Age, y | .6 | |||||
| 15-29 | 216 | 192 (20) | 24 (19) | 11 | N/A | 21 |
| 30-39 | 242 | 220 (22) | 22 (17) | 9 | N/A | 24 |
| 40-49 | 317 | 272 (28) | 45 (35) | 14 | N/A | 28 |
| 50-59 | 305 | 273 (28) | 32 (25) | 10 | N/A | 27 |
| 60 or older | 27 | 23 (2) | 4 (3) | 15 | N/A | 41 |
| Median | 42 | 42 | 43 | N/A | N/A | N/A |
| WBC, × 109/L | .006 | |||||
| Less than 10 | 317 | 292 (30) | 25 (20) | 8 | N/A | 10 |
| 10-19.9 | 173 | 156 (16) | 17 (13) | 10 | N/A | 23 |
| 20-49.9 | 252 | 220 (23) | 32 (25) | 13 | N/A | 27 |
| 50-99.9 | 173 | 144 (15) | 29 (23) | 17 | N/A | 35 |
| 100 or above | 171 | 148 (15) | 23 (18) | 13 | N/A | 47 |
| Unknown | 21 | 20 | 1 | 5 | N/A | 19 |
| Median | 24.5 | 23 | 38.3 | N/A | N/A | N/A |
P values relate to the incidence of FLT3/TKD mutations using the Mantel-Haenszel test for trend in age and WBC count and, otherwise, χ2 or the Fisher exact test for heterogeneity.
N/A indicates not applicable.