Table 2

RV and LV hot spots containing at least 1 proto-oncogene and/or cancer-associated CIS

ChromosomeRange, bpNo. hitsGene symbolOrigin (no. hits)
RV hot spots 
    14q24.3 13 882 C14orf43, PNMA1* CB-RV (2) CB-SIN-RV (2) 
    11p13 48 661 AF116668, LMO2* BM-ADA (1) CB-RV (1) CB-SIN-RV (1) 
    17q11.2 7 827 EVI2A,*EVI2B, *NF1,*OMG BM-X-SCID (1) CB-RV (2) 
    10q25.2 1 920 ADD3* BM-ADA (1) CB-SIN-RV (1) 
    11q23.2 22 851 ZBTB16* BM-ADA (1) CB-RV (1) 
    11q24.3 14 147 FLI1* BM-ADA (1) CB-RV (1) 
    12p13.2 7 360 ETV6* CB-RV (2) 
    16p13.11 18 559 ABCC1* BM-ADA (1) CB-RV (1) 
    19p13.13 137 BTBD14B, LYL1,*NFIX,*TRMT1 BM-X-SCID (1) CB-RV (1) 
    20p12.3 136 PLCB1* CB-SIN-RV (2) 
    20q13.12 19 100 C20orf121, PKIG,*SERINC3* CB-RV (2) 
    22q13.1 29 588 AB051446, MKL1,*RUTBC3* BM-X-SCID (1) CB-SIN-RV (1) 
    2p11.2 779 CAPG,*LOC284948, RBED1 PB-ND (2) 
    2p21 975 AK025445, MGC40574, THADA,*ZFP36L2* CB-RV (2) 
    4p14 11 999 N4BP2, RHOH* CB-RV (2) 
    6q23.3 9 422 MYB* CB-RV (2) 
    6p24.3 1 991 RREB1* CB-RV (1) CB-SIN-RV (1) 
LV hot spots 
    9q34.3 31 043 AK130247, C9orf163, INPP5E, NOTCH1,*PMPCA,     DCCAG3 CB-SIN-LV (2) CB-LV (1) 
    2p21 22 106 THADA* CB-SIN-LV (1) CB-LV (1) 
    20p12.3 24 132 PLCB1* CB-LV (2) 
    17p13.3 25 818 RUTBC1, SMG6,*SRR, TSR1 CB-LV (2) 
Controls 
6q25.1 4 561 ESR1* — 
ChromosomeRange, bpNo. hitsGene symbolOrigin (no. hits)
RV hot spots 
    14q24.3 13 882 C14orf43, PNMA1* CB-RV (2) CB-SIN-RV (2) 
    11p13 48 661 AF116668, LMO2* BM-ADA (1) CB-RV (1) CB-SIN-RV (1) 
    17q11.2 7 827 EVI2A,*EVI2B, *NF1,*OMG BM-X-SCID (1) CB-RV (2) 
    10q25.2 1 920 ADD3* BM-ADA (1) CB-SIN-RV (1) 
    11q23.2 22 851 ZBTB16* BM-ADA (1) CB-RV (1) 
    11q24.3 14 147 FLI1* BM-ADA (1) CB-RV (1) 
    12p13.2 7 360 ETV6* CB-RV (2) 
    16p13.11 18 559 ABCC1* BM-ADA (1) CB-RV (1) 
    19p13.13 137 BTBD14B, LYL1,*NFIX,*TRMT1 BM-X-SCID (1) CB-RV (1) 
    20p12.3 136 PLCB1* CB-SIN-RV (2) 
    20q13.12 19 100 C20orf121, PKIG,*SERINC3* CB-RV (2) 
    22q13.1 29 588 AB051446, MKL1,*RUTBC3* BM-X-SCID (1) CB-SIN-RV (1) 
    2p11.2 779 CAPG,*LOC284948, RBED1 PB-ND (2) 
    2p21 975 AK025445, MGC40574, THADA,*ZFP36L2* CB-RV (2) 
    4p14 11 999 N4BP2, RHOH* CB-RV (2) 
    6q23.3 9 422 MYB* CB-RV (2) 
    6p24.3 1 991 RREB1* CB-RV (1) CB-SIN-RV (1) 
LV hot spots 
    9q34.3 31 043 AK130247, C9orf163, INPP5E, NOTCH1,*PMPCA,     DCCAG3 CB-SIN-LV (2) CB-LV (1) 
    2p21 22 106 THADA* CB-SIN-LV (1) CB-LV (1) 
    20p12.3 24 132 PLCB1* CB-LV (2) 
    17p13.3 25 818 RUTBC1, SMG6,*SRR, TSR1 CB-LV (2) 
Controls 
6q25.1 4 561 ESR1* — 

Range indicates the maximum distance between hits contained in each hot spot. For the complete list of hot spots, see Table S5.

CB-RV indicates CB-derived CD34+ cells transduced with wt-LTR RV; CB-SIN-RV, CB-derived CD34+ cells transduced with SIN-LTR RV; BM-ADA, BM-derived CD34+ cells from patients with ADA-SCID transduced with wt-LTR RV; BM-X-SCID, BM-derived CD34+ cells from patients with X-SCID transduced with wt-LTR RV; PB-ND, PB-derived CD34+ cells from healthy donor transduced with wt-LTR RV; CB-LV, CB-derived CD34+ cells transduced with wt-LTR LV; and CB-SIN-LV, CB-derived CD34+ cells transduced with SIN-LTR LV; —indicates not applicable.

*

Indicates proto-oncogene or CIS.

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