Table 3 Univariate and multivariable Cox... | American Society of Hematology

Table 3

Univariate and multivariable Cox models for the 4 SNP risk score

Number of deleterious genotypes*	N	% Dead	Univariate model		Multivariable model†
Number of deleterious genotypes*	N	% Dead	HR	95% CI	HR	95% CI
0	36	5.6%	1.00	reference	1.00	reference
1	85	15.3%	2.92	0.76-1.0	3.46	0.78-15.4
2	104	22.1%	4.81	1.13-20.4	5.76	1.35-24.6
3,4	53	39.6%	9.58	2.24-41.0	12.6	2.92-54.4
P-trend	NA	NA	P < .001	NA	P < .001	NA
Continuous	NA	NA	1.92	1.42-2.59	2.06	1.52-2.79

Number of deleterious genotypes*	N	% Dead	Univariate model		Multivariable model†
Number of deleterious genotypes*	N	% Dead	HR	95% CI	HR	95% CI
0	36	5.6%	1.00	reference	1.00	reference
1	85	15.3%	2.92	0.76-1.0	3.46	0.78-15.4
2	104	22.1%	4.81	1.13-20.4	5.76	1.35-24.6
3,4	53	39.6%	9.58	2.24-41.0	12.6	2.92-54.4
P-trend	NA	NA	P < .001	NA	P < .001	NA
Continuous	NA	NA	1.92	1.42-2.59	2.06	1.52-2.79

NA indicates not applicable.

IL8 (rs4073), IL2 (rs2069762), IL12B (rs3212227), and IL1RN (rs454078) as coded in Table 2

Model adjusted for age and clinical and demographic risk scores.