Genotype distribution of progeny obtained from intercross of Ggcx+/− mice
| . | Total no. . | +/+, n (%) . | +/−, n (%) . | −/−, n (%) . | P . |
|---|---|---|---|---|---|
| Term pups | 217 | 85 (39.2) | 128 (59) | 5 (2.3) | < .001 |
| 18 dpc | 164 | 56 (34.2) | 88 (53.7) | 20 (12.2) | < .001 |
| 9.5 dpc | 146 | 37 (25.3) | 72 (49.3) | 37 (25.3) | > .9 |
| . | Total no. . | +/+, n (%) . | +/−, n (%) . | −/−, n (%) . | P . |
|---|---|---|---|---|---|
| Term pups | 217 | 85 (39.2) | 128 (59) | 5 (2.3) | < .001 |
| 18 dpc | 164 | 56 (34.2) | 88 (53.7) | 20 (12.2) | < .001 |
| 9.5 dpc | 146 | 37 (25.3) | 72 (49.3) | 37 (25.3) | > .9 |
The data were derived from an intercross of Ggcx+/− animals derived from a backcross to C57BL/6 mice of 4 generations or greater. The expected percentages for each genotype from this cross are 25% (Ggcx+/+), 50% (Ggcx+/−), and 25% (Ggcx−/−). The number of Ggcx−/− embryos observed at 18 dpc is approximately one-half of the expected 25%. P values obtained by a χ2 test comparing the expected and observed numbers of animals for each indicated genotype are given in the last column. n indicates number of mice.