Table 2

Summary of 80 candidate gene single-nucleotide polymorphisms

GeneSNP IDGene descriptionChromosomeMinor allele frequencyMinor allele
Apoptosis pathway (n = 30)      
    BCL2 rs1801018 B-cell CLL/lymphoma 2 18 0.414 G 
    BCL2 rs2279115 B-cell CLL/lymphoma 2 18 0.486 C 
    BAX rs11667351 BCL2-associated X protein 19 0.129 G 
    BCL2L2 rs7042474 BCL2-like 2 9 0.127 T 
    BCL6 rs1056932 B-cell CLL/lymphoma 6 3 0.341 C 
    BCL6 rs11545363 B-cell CLL/lymphoma 6 3 0 C 
    BCL2L11 rs6746608 BCL2-like 11 2 0.450 A 
    BCL2L11 rs12613243 BCL2-like 11 2 0.072 C 
    BIRC5 rs9904341 Survivin 17 0.328 C 
    BIRC5 rs2071214 Survivin 17 0.057 G 
    CASP1 rs580253 Caspase 1 11 0.184 T 
    CASP3 rs1049253 Caspase 3 4 0.167 C 
    CASP7 rs7922608 Caspase 7 10 0.313 G 
    CASP8 rs1045485 Caspase 8 2 0.126 C 
    CASP8 rs3769818 Caspase 8 2 0.276 T 
    CASP8 rs3834129 Caspase 8 2 0.461 C 
    CASP9 rs4645981 Caspase 9 1 0 C 
    CASP10 rs13010627 Caspase 10 2 0.074 A 
    CASP10 rs13006529 Caspase 10 2 0.458 A 
    FASL rs763110 Fas ligand (TNF superfamily 6) 1 0.383 T 
    FAS rs2234767 Fas (TNF receptor superfamily 6) 10 0.114 A 
    FAS rs1800682 Fas (TNF receptor superfamily 6) 10 0.473 C 
    FAS rs3218619 Fas (TNF receptor superfamily 6) 10 0.003 A 
    FAS rs3218612 Fas (TNF receptor superfamily 6) 10 0.042 G 
    FAS rs2234978 Fas (TNF receptor superfamily 6) 10 0.331 T 
    APAF1 rs1439123 Apoptotic peptidase activating factor 1 12 0.224 C 
    APAF1 rs2288713 Apoptotic peptidase activating factor 1 12 0.103 G 
    TNFR2 rs1061622 TNF receptor superfamily, member 1B 1 0.22 G 
    PDCD1 rs2227981 Programmed cell death 1 2 0.418 T 
    GZMB rs7144366 Granzyme B 14 0.391 T 
Angiogenesis (n = 7)      
    VEGFA rs699947 VEGFA 6 0.476 A 
    VEGFA rs833061 VEGFA 6 0.480 C 
    VEGFA rs2010963 VEGFA 6 0.335 C 
    VEGFA rs3025039 VEGFA 6 0.142 T 
    VEGFR2 rs1531289 VEGF receptor 2 4 0.302 A 
    VEGFR2 rs1870377 VEGF receptor 2 4 0.228 A 
    VEGFR2 rs2305948 VEGF receptor 2 4 0.092 T 
Myeloid growth (n = 14)      
    FLT3 rs35602083 fms-related tyrosine kinase 3 13 0.035 T 
    CSF3 rs25645 G-CSF 17 0.389 A 
    CSF3 rs1042658 G-CSF 17 0.337 T 
    CSF2 rs25882 GM-CSF 5 0.225 C 
    JAK3 rs3008 Janus kinase 3 19 0.447 C 
    JAK3 rs3212713 Janus kinase 3 19 0.341 A 
    IL1A rs17561 Interleukin 1 α 2 0.274 T 
    IL1A rs1800587 Interleukin 1 α 2 0.277 T 
    IL1B rs1143634 Interleukin 1 β 2 0.222 T 
    IL1B rs1143633 Interleukin 1 β 2 0.358 A 
    IL1B rs1143627 Interleukin 1 β 2 0.371 C 
    IL1B rs16944 Interleukin 1 β 2 0.371 A 
    IL1R rs2228139 Interleukin 1 receptor, type I 2 0.060 G 
    IL1R rs315952 Interleukin 1 receptor antagonist 2 0.282 C 
WT1 signaling (n = 7)      
    WT1 rs1799937 Wilms tumor 1 11 0.244 C 
    WT1 rs2234591 Wilms tumor 1 11 0.006 G 
    WT1 rs2234590 Wilms tumor 1 11 0.003 G 
    WT1 rs2301254 Wilms tumor 1 11 0.380 C 
    WT1 rs2301252 Wilms tumor 1 11 0.380 T 
    WT1 rs2301250 Wilms tumor 1 11 0.380 T 
    WT1 rs6508 Wilms tumor 1 11 0.067 A 
Xenobiotic metabolism (n = 13)      
    ABCB1 rs1045642 Multidrug resistance 1 7 0.474 C 
    ABCB1 rs2032582 Multidrug resistance 1 7 0.466 T/G/A 
    ABCB1 rs1128503 Multidrug resistance 1 7 0.440 T 
    ABCG2 rs2231142 Breast cancer resistance protein 4 0.102 A 
    ABCG2 rs2231137 Breast cancer resistance protein 4 0.057 A 
    CYP3A5 rs776746 Cytochrome P450, family 3, A5 7 0.060 A 
    CYP3A5 rs28383469 Cytochrome P450, family 3, A5 7 0 G 
    CYP3A5 rs28383468 Cytochrome P450, family 3, A5 7 0.006 T 
    HOCT1 rs1867351 Solute carrier family 22, member 1 6 0.227 G 
    HOCT1 rs12208357 Solute carrier family 22, member 1 6 0.070 T 
    HOCT1 rs683369 Solute carrier family 22, member 1 6 0.201 G 
    HOCT1 rs2282143 Solute carrier family 22, member 1 6 0.019 T 
    HOCT1 rs628031 Solute carrier family 22, member 1 6 0.374 A 
Interferon signaling (n = 4)      
    IFNG rs1861494 Interferon γ 12 0.274 C 
    IFNG rs2069705 Interferon γ 12 0.326 C 
    IFNGR1 rs3799488 Interferon γ receptor 1 6 0.105 C 
    IFNGR2 rs9808753 Interferon γ receptor 2 21 0.164 G 
Other (n = 5)      
    GNB3 rs5443 G protein β polypeptide 3 12 0.338 T 
    ULK3 rs2290573 Unc-51–like kinase 3 15 0.449 T 
    ORM rs1126724 Orosomucoid 1 9 0 G 
    ORM rs3182041 Orosomucoid 1 9 0.003 G 
    PTK2 rs4554515 PTK2 protein tyrosine kinase 2 8 0.452 G 
GeneSNP IDGene descriptionChromosomeMinor allele frequencyMinor allele
Apoptosis pathway (n = 30)      
    BCL2 rs1801018 B-cell CLL/lymphoma 2 18 0.414 G 
    BCL2 rs2279115 B-cell CLL/lymphoma 2 18 0.486 C 
    BAX rs11667351 BCL2-associated X protein 19 0.129 G 
    BCL2L2 rs7042474 BCL2-like 2 9 0.127 T 
    BCL6 rs1056932 B-cell CLL/lymphoma 6 3 0.341 C 
    BCL6 rs11545363 B-cell CLL/lymphoma 6 3 0 C 
    BCL2L11 rs6746608 BCL2-like 11 2 0.450 A 
    BCL2L11 rs12613243 BCL2-like 11 2 0.072 C 
    BIRC5 rs9904341 Survivin 17 0.328 C 
    BIRC5 rs2071214 Survivin 17 0.057 G 
    CASP1 rs580253 Caspase 1 11 0.184 T 
    CASP3 rs1049253 Caspase 3 4 0.167 C 
    CASP7 rs7922608 Caspase 7 10 0.313 G 
    CASP8 rs1045485 Caspase 8 2 0.126 C 
    CASP8 rs3769818 Caspase 8 2 0.276 T 
    CASP8 rs3834129 Caspase 8 2 0.461 C 
    CASP9 rs4645981 Caspase 9 1 0 C 
    CASP10 rs13010627 Caspase 10 2 0.074 A 
    CASP10 rs13006529 Caspase 10 2 0.458 A 
    FASL rs763110 Fas ligand (TNF superfamily 6) 1 0.383 T 
    FAS rs2234767 Fas (TNF receptor superfamily 6) 10 0.114 A 
    FAS rs1800682 Fas (TNF receptor superfamily 6) 10 0.473 C 
    FAS rs3218619 Fas (TNF receptor superfamily 6) 10 0.003 A 
    FAS rs3218612 Fas (TNF receptor superfamily 6) 10 0.042 G 
    FAS rs2234978 Fas (TNF receptor superfamily 6) 10 0.331 T 
    APAF1 rs1439123 Apoptotic peptidase activating factor 1 12 0.224 C 
    APAF1 rs2288713 Apoptotic peptidase activating factor 1 12 0.103 G 
    TNFR2 rs1061622 TNF receptor superfamily, member 1B 1 0.22 G 
    PDCD1 rs2227981 Programmed cell death 1 2 0.418 T 
    GZMB rs7144366 Granzyme B 14 0.391 T 
Angiogenesis (n = 7)      
    VEGFA rs699947 VEGFA 6 0.476 A 
    VEGFA rs833061 VEGFA 6 0.480 C 
    VEGFA rs2010963 VEGFA 6 0.335 C 
    VEGFA rs3025039 VEGFA 6 0.142 T 
    VEGFR2 rs1531289 VEGF receptor 2 4 0.302 A 
    VEGFR2 rs1870377 VEGF receptor 2 4 0.228 A 
    VEGFR2 rs2305948 VEGF receptor 2 4 0.092 T 
Myeloid growth (n = 14)      
    FLT3 rs35602083 fms-related tyrosine kinase 3 13 0.035 T 
    CSF3 rs25645 G-CSF 17 0.389 A 
    CSF3 rs1042658 G-CSF 17 0.337 T 
    CSF2 rs25882 GM-CSF 5 0.225 C 
    JAK3 rs3008 Janus kinase 3 19 0.447 C 
    JAK3 rs3212713 Janus kinase 3 19 0.341 A 
    IL1A rs17561 Interleukin 1 α 2 0.274 T 
    IL1A rs1800587 Interleukin 1 α 2 0.277 T 
    IL1B rs1143634 Interleukin 1 β 2 0.222 T 
    IL1B rs1143633 Interleukin 1 β 2 0.358 A 
    IL1B rs1143627 Interleukin 1 β 2 0.371 C 
    IL1B rs16944 Interleukin 1 β 2 0.371 A 
    IL1R rs2228139 Interleukin 1 receptor, type I 2 0.060 G 
    IL1R rs315952 Interleukin 1 receptor antagonist 2 0.282 C 
WT1 signaling (n = 7)      
    WT1 rs1799937 Wilms tumor 1 11 0.244 C 
    WT1 rs2234591 Wilms tumor 1 11 0.006 G 
    WT1 rs2234590 Wilms tumor 1 11 0.003 G 
    WT1 rs2301254 Wilms tumor 1 11 0.380 C 
    WT1 rs2301252 Wilms tumor 1 11 0.380 T 
    WT1 rs2301250 Wilms tumor 1 11 0.380 T 
    WT1 rs6508 Wilms tumor 1 11 0.067 A 
Xenobiotic metabolism (n = 13)      
    ABCB1 rs1045642 Multidrug resistance 1 7 0.474 C 
    ABCB1 rs2032582 Multidrug resistance 1 7 0.466 T/G/A 
    ABCB1 rs1128503 Multidrug resistance 1 7 0.440 T 
    ABCG2 rs2231142 Breast cancer resistance protein 4 0.102 A 
    ABCG2 rs2231137 Breast cancer resistance protein 4 0.057 A 
    CYP3A5 rs776746 Cytochrome P450, family 3, A5 7 0.060 A 
    CYP3A5 rs28383469 Cytochrome P450, family 3, A5 7 0 G 
    CYP3A5 rs28383468 Cytochrome P450, family 3, A5 7 0.006 T 
    HOCT1 rs1867351 Solute carrier family 22, member 1 6 0.227 G 
    HOCT1 rs12208357 Solute carrier family 22, member 1 6 0.070 T 
    HOCT1 rs683369 Solute carrier family 22, member 1 6 0.201 G 
    HOCT1 rs2282143 Solute carrier family 22, member 1 6 0.019 T 
    HOCT1 rs628031 Solute carrier family 22, member 1 6 0.374 A 
Interferon signaling (n = 4)      
    IFNG rs1861494 Interferon γ 12 0.274 C 
    IFNG rs2069705 Interferon γ 12 0.326 C 
    IFNGR1 rs3799488 Interferon γ receptor 1 6 0.105 C 
    IFNGR2 rs9808753 Interferon γ receptor 2 21 0.164 G 
Other (n = 5)      
    GNB3 rs5443 G protein β polypeptide 3 12 0.338 T 
    ULK3 rs2290573 Unc-51–like kinase 3 15 0.449 T 
    ORM rs1126724 Orosomucoid 1 9 0 G 
    ORM rs3182041 Orosomucoid 1 9 0.003 G 
    PTK2 rs4554515 PTK2 protein tyrosine kinase 2 8 0.452 G 
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