Histopathologic staging of lymph nodes in mycosis fungoides and Sézary syndrome
| Updated ISCL/EORTC classification . | Dutch system58 . | NCI-VA classification13,57,59 . |
|---|---|---|
| N1 | Grade 1: dermatopathic lymphadenopathy (DL) | LN0: no atypical lymphocytes |
| LN1: occasional and isolated atypical lymphocytes (not arranged in clusters) | ||
| LN2: many atypical lymphocytes or in 3-6 cell clusters | ||
| N2 | Grade 2: DL; early involvement by MF (presence of cerebriform nuclei > 7.5 μm) | LN3: aggregates of atypical lymphocytes; nodal architecture preserved |
| N3 | Grade 3: partial effacement of LN architecture; many atypical cerebriform mononuclear cells (CMCs) Grade 4: complete effacement | LN4: partial/complete effacement of nodal architecture by atypical lymphocytes or frankly neoplastic cells |
| Updated ISCL/EORTC classification . | Dutch system58 . | NCI-VA classification13,57,59 . |
|---|---|---|
| N1 | Grade 1: dermatopathic lymphadenopathy (DL) | LN0: no atypical lymphocytes |
| LN1: occasional and isolated atypical lymphocytes (not arranged in clusters) | ||
| LN2: many atypical lymphocytes or in 3-6 cell clusters | ||
| N2 | Grade 2: DL; early involvement by MF (presence of cerebriform nuclei > 7.5 μm) | LN3: aggregates of atypical lymphocytes; nodal architecture preserved |
| N3 | Grade 3: partial effacement of LN architecture; many atypical cerebriform mononuclear cells (CMCs) Grade 4: complete effacement | LN4: partial/complete effacement of nodal architecture by atypical lymphocytes or frankly neoplastic cells |