Table 2 Effects of 100 NA,RO-H on in... | American Society of Hematology

Table 2

Effects of ¹⁰⁰NA,RO-H on in vivo growth of CAG heparanase-low myeloma cells

Mouse tag no.	¹⁰⁰NA,RO-H, mg/kg per d	Tumor wet weight,* mg	Serum kappa light chain,† ng/mL
502B	0	400	7424
3F44	0	140	2676
133F	0	200	2325
3648	0	110	1407
4B1F	0	130	1432
611A	0	100	3461
1949	18	50	523
793A	18	30	6
C573	18	0	2
353A	18	0	0
7C23	18	0	4
5D4B	18	0	116

Mouse tag no.	¹⁰⁰NA,RO-H, mg/kg per d	Tumor wet weight,* mg	Serum kappa light chain,† ng/mL
502B	0	400	7424
3F44	0	140	2676
133F	0	200	2325
3648	0	110	1407
4B1F	0	130	1432
611A	0	100	3461
1949	18	50	523
793A	18	30	6
C573	18	0	2
353A	18	0	0
7C23	18	0	4
5D4B	18	0	116

Mean tumor weights: No ¹⁰⁰NA,RO-H, 180 mg; 18 mg/kg per day group, 40 mg (two tumors only). No ¹⁰⁰NA,RO-H group versus 18 mg/kg per day group, P = .003.

†

Mean kappa levels at termination of treatment: No ¹⁰⁰NA,RO-H, 3121 ng; 18 mg/kg per day group, 109 ng; No ¹⁰⁰NA,RO-H S group versus 18 mg/kg per day group, P = .004.

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