Table 3 MLPA can detect deletions when... | American Society of Hematology

Table 3

MLPA can detect deletions when the proportion of patient DNA known to harbor deletions is 60% or greater

	ASS	PRDM12	EXOSC2	ABL exon 1	BCR exon 16	FLJ31568
100%	del	del	del	del	del	del
80%	del	del	del	del	del	del
60%	del	del	del	del	del	del
40%	del	+	del	del	+	+
20%	+	+	del	+	+	+
0%	+	+	+	+	+	+

	ASS	PRDM12	EXOSC2	ABL exon 1	BCR exon 16	FLJ31568
100%	del	del	del	del	del	del
80%	del	del	del	del	del	del
60%	del	del	del	del	del	del
40%	del	+	del	del	+	+
20%	+	+	del	+	+	+
0%	+	+	+	+	+	+

At 60% patient DNA and over, all 6 markers are correctly scored as deleted, whereas at lower dilutions, deletions are often missed.

+ indicates not deleted (dosage quotient ≥ 0.7); del, deleted (dosage quotient < 0.7).