Table 3 Renal function, anticoagulation... | American Society of Hematology

Table 3

Renal function, anticoagulation intensity at first control, and lepirudin dose (investigation cohort)

CrCl, mL/minAnticoagulation intensity*	n	Lepirudin dose, mg kg⁻¹ hour⁻¹		P
		Median (interquartile range)		P
		Start	End	Paired
More than 60, n = 29
Over	8	0.098 (0.081-0.124)	0.033 (0.014-0.055)	0.007
Target	17	0.078 (0.049-0.093)	0.034 (0.027-0.058)	0.001
Under	4	0.022 (0.014-0.039)	0.036 (0.030-0.042)	0.235
		0.001	0.867		ANOVA
30-60, n = 15
Over	6	0.098 (0.086-0.102)	0.015 (0.011-0.029)	0.005
Target	7	0.040 (0.025-0.050)	0.037 (0.017-0.047)	0.294
Under	2	0.010 (0.009-0.011)	0.011 (0.007-0.016)	0.737
		< 0.001	0.313		ANOVA
Less than 30, n = 9
Over	0
Target	7	0.013 (0.008-0.026)	0.007 (0.003-0.018)	0.182
Under	2	0.008 (0.006-0.009)	0.005	NA
		0.316	NA		ANOVA

CrCl, mL/minAnticoagulation intensity*	n	Lepirudin dose, mg kg⁻¹ hour⁻¹		P
		Median (interquartile range)		P
		Start	End	Paired
More than 60, n = 29
Over	8	0.098 (0.081-0.124)	0.033 (0.014-0.055)	0.007
Target	17	0.078 (0.049-0.093)	0.034 (0.027-0.058)	0.001
Under	4	0.022 (0.014-0.039)	0.036 (0.030-0.042)	0.235
		0.001	0.867		ANOVA
30-60, n = 15
Over	6	0.098 (0.086-0.102)	0.015 (0.011-0.029)	0.005
Target	7	0.040 (0.025-0.050)	0.037 (0.017-0.047)	0.294
Under	2	0.010 (0.009-0.011)	0.011 (0.007-0.016)	0.737
		< 0.001	0.313		ANOVA
Less than 30, n = 9
Over	0
Target	7	0.013 (0.008-0.026)	0.007 (0.003-0.018)	0.182
Under	2	0.008 (0.006-0.009)	0.005	NA
		0.316	NA		ANOVA

Over indicates TT/aPTT above therapeutic ranges; Target, TT/aPTT within therapeutic ranges; Under, TT/aPTT below therapeutic ranges 4 hours after lepirudin start; and NA, not applicable.

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