Patient characteristics
| Characteristics . | . | Investigation cohort (N = 53) . | Evaluation cohort (N = 15) . | ||
|---|---|---|---|---|---|
| Personal data | |||||
| Age, y | Median (IQR) | 69.4 | (58.9-74.0) | 69.2 | (61.2-74.7) |
| Sex, females | n (%) | 21 | (40) | 6 | (40) |
| Body weight, kg | Median (IQR) | 79.7 | (70.7-87.7) | 77.5 | (71.0-80.0) |
| HIT workup | |||||
| Platelet count at day 0, 109/L | Median (IQR) | 53 | (37-88) | 53 | (28-66) |
| Thrombosis at day 0 (HIT-T) | n (%) | 27 | (51) | 7 | (47) |
| D-dimer at day 0, μg/L | Median (IQR) | 5510 | (3401-6129) | 4874 | (3277-10 688) |
| Pretest score (4T) | Median (range) | 4 | (4-7) | 4 | (4-6) |
| Titer (ID-HPF4-PaGIA) | Median (range) | 8 | (2-128) | 4 | (2-256) |
| OD (GTI-PF4) | Median (IQR) | 2.801 | (1.822-3.000) | 2.401 | (1.300-2.868) |
| Renal function | |||||
| Creatinine, μmol/L | Median (IQR) | 114 | (75-150) | 130 | (81-198) |
| CrCl > 60 mL/min | n (%) | 29 | (55) | 5 | (33.3) |
| CrCl 30-60 mL/min | n (%) | 15 | (28) | 5 | (33.3) |
| CrCl < 30 mL/min | n (%) | 9 | (17) | 5 | (33.3) |
| Characteristics . | . | Investigation cohort (N = 53) . | Evaluation cohort (N = 15) . | ||
|---|---|---|---|---|---|
| Personal data | |||||
| Age, y | Median (IQR) | 69.4 | (58.9-74.0) | 69.2 | (61.2-74.7) |
| Sex, females | n (%) | 21 | (40) | 6 | (40) |
| Body weight, kg | Median (IQR) | 79.7 | (70.7-87.7) | 77.5 | (71.0-80.0) |
| HIT workup | |||||
| Platelet count at day 0, 109/L | Median (IQR) | 53 | (37-88) | 53 | (28-66) |
| Thrombosis at day 0 (HIT-T) | n (%) | 27 | (51) | 7 | (47) |
| D-dimer at day 0, μg/L | Median (IQR) | 5510 | (3401-6129) | 4874 | (3277-10 688) |
| Pretest score (4T) | Median (range) | 4 | (4-7) | 4 | (4-6) |
| Titer (ID-HPF4-PaGIA) | Median (range) | 8 | (2-128) | 4 | (2-256) |
| OD (GTI-PF4) | Median (IQR) | 2.801 | (1.822-3.000) | 2.401 | (1.300-2.868) |
| Renal function | |||||
| Creatinine, μmol/L | Median (IQR) | 114 | (75-150) | 130 | (81-198) |
| CrCl > 60 mL/min | n (%) | 29 | (55) | 5 | (33.3) |
| CrCl 30-60 mL/min | n (%) | 15 | (28) | 5 | (33.3) |
| CrCl < 30 mL/min | n (%) | 9 | (17) | 5 | (33.3) |
IQR indicates interquartile range; day 0, day of clinical and laboratory evaluation for suspected HIT; HIT-T, HIT with thrombosis; OD, optical density; and CrCl, creatinine clearance.