Defining target ranges for lepirudin
| Lepirudin, μg/mL . | TT1.5, seconds . | TT5, seconds . | aPTT, seconds . | aPTT ratio . |
|---|---|---|---|---|
| minimum-maximum . | minimum-maximum . | median (IQR) . | median (IQR) . | |
| 0.00 | 13.2-16.2 | 29.0 (28.8-30.2) | 1 | |
| 0.10 | 21.4-29.6 | 39.0 (38.8-41.0) | 1.35 (1.34-1.38) | |
| 0.15 | 34.4-46.5 | 42.1 (41.2-45.5) | 1.45 (1.42-1.53) | |
| 0.25 | No clot | 8.5-9.4 | 49.4 (46.9-52.0) | 1.71 (1.62-1.75) |
| 0.50 | No clot | 16.1-38.4 | 59.8 (58.4-63.8) | 2.06 (2.02-2.15) |
| 0.75 | No clot | 50.6-No clot | 69.0 (66.2-73.2) | 2.39 (2.33-2.43) |
| 1.00 | No clot | 91.3-No clot | 72.9 (70.8-81.2) | 2.56 (2.46-2.69) |
| 1.25 | No clot | No clot | 79.8 (77.3-86.5) | 2.81 (2.68-2.87) |
| 1.50 | No clot | No clot | 85.1 (82.1-92.3) | 3.01 (2.84-3.06) |
| 1.75 | No clot | No clot | 90.9 (86.3-98.3) | 3.15 (3.03-3.25) |
| 2.00 | No clot | No clot | 95.8 (92.0-102.7) | 3.29 (3.18-3.47) |
| Lepirudin, μg/mL . | TT1.5, seconds . | TT5, seconds . | aPTT, seconds . | aPTT ratio . |
|---|---|---|---|---|
| minimum-maximum . | minimum-maximum . | median (IQR) . | median (IQR) . | |
| 0.00 | 13.2-16.2 | 29.0 (28.8-30.2) | 1 | |
| 0.10 | 21.4-29.6 | 39.0 (38.8-41.0) | 1.35 (1.34-1.38) | |
| 0.15 | 34.4-46.5 | 42.1 (41.2-45.5) | 1.45 (1.42-1.53) | |
| 0.25 | No clot | 8.5-9.4 | 49.4 (46.9-52.0) | 1.71 (1.62-1.75) |
| 0.50 | No clot | 16.1-38.4 | 59.8 (58.4-63.8) | 2.06 (2.02-2.15) |
| 0.75 | No clot | 50.6-No clot | 69.0 (66.2-73.2) | 2.39 (2.33-2.43) |
| 1.00 | No clot | 91.3-No clot | 72.9 (70.8-81.2) | 2.56 (2.46-2.69) |
| 1.25 | No clot | No clot | 79.8 (77.3-86.5) | 2.81 (2.68-2.87) |
| 1.50 | No clot | No clot | 85.1 (82.1-92.3) | 3.01 (2.84-3.06) |
| 1.75 | No clot | No clot | 90.9 (86.3-98.3) | 3.15 (3.03-3.25) |
| 2.00 | No clot | No clot | 95.8 (92.0-102.7) | 3.29 (3.18-3.47) |
Pooled normal plasma was spiked with increasing concentrations of lepirudin. Thrombin time (TT) and activated partial thromboplastin time (aPTT) were measured with different reagent lots (n = 7). See “Lepirudin monitoring” for details.
No clot signifies TT > 120 seconds.