PGA of clinical condition: grades and response criteria
| Grade . | Response* . | Comparison with baseline . |
|---|---|---|
| 0: completely clear | CCR/CR† | No evidence of disease (100% improvement) |
| 1: almost clear | PR | Very significant clearance (≥ 90% to < 100%) |
| 2: marked improvement | PR | Significant improvement (≥ 75% to < 90%); some evidence of disease remains |
| 3: moderate improvement | PR | Intermediate between slight and marked improvement (≥ 50% to < 75%) |
| 4: slight improvement | SD | Some improvement (≥ 25% to < 50%), but significant evidence of disease has not changed |
| 5: no change | SD | Disease has not changed (± < 25%) |
| 6: worse | PD | Disease is worse by 25% or more |
| Grade . | Response* . | Comparison with baseline . |
|---|---|---|
| 0: completely clear | CCR/CR† | No evidence of disease (100% improvement) |
| 1: almost clear | PR | Very significant clearance (≥ 90% to < 100%) |
| 2: marked improvement | PR | Significant improvement (≥ 75% to < 90%); some evidence of disease remains |
| 3: moderate improvement | PR | Intermediate between slight and marked improvement (≥ 50% to < 75%) |
| 4: slight improvement | SD | Some improvement (≥ 25% to < 50%), but significant evidence of disease has not changed |
| 5: no change | SD | Disease has not changed (± < 25%) |
| 6: worse | PD | Disease is worse by 25% or more |
CCR indicates clinical complete response; CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease.
*All responses had to be confirmed by a second assessment after at least 4 weeks.
†CR is CCR plus a cutaneous biopsy from a cleared lesion documenting absence of histologic signs of MF.