Table 3

Numbers of peripheral T and B cells of tPtch−/− and control mice 19 days after onset of tamoxifen treatment

Controls
tPtch−/− (19 days)
MeanDeviationnMeanDeviationnP
Ly, % FACS 46.70* 11.63* 7 23.34* 9.53* 5 .012* 
B cells, % 13.98* 3.74* 7 4.71* 2.33* 5 .004* 
CD4+ T cells, % 6.94 3.50 7 4.83 1.36 5 .333 
CD8+ T cells, % 2.90 1.61 7 2.17 1.06 5 .454 
Controls
tPtch−/− (19 days)
MeanDeviationnMeanDeviationnP
Ly, % FACS 46.70* 11.63* 7 23.34* 9.53* 5 .012* 
B cells, % 13.98* 3.74* 7 4.71* 2.33* 5 .004* 
CD4+ T cells, % 6.94 3.50 7 4.83 1.36 5 .333 
CD8+ T cells, % 2.90 1.61 7 2.17 1.06 5 .454 

Cell numbers were determined by FACS analyses from the lymphocyte gate using anti-B220 (B cells), and anti-CD4 and anti-CD8 (T cells) antibodies.

Ly indicates lymphocytes.

*

Significant differences (P value < .05 by Mann-Whitney U test) between tPtch−/− and control mice.

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