Table 2

Hematologic parameters of tPtch−/− and control mice 19 days after the onset of tamoxifen treatment

Controls
tPtch−/− (19 days)
MeanDeviationnMeanDeviationnP
Hkt 0.425 0.028 7 0.409 0.062 5 .663 
Hgb, g/dL 134.0 6.0 6 131.0 18.0 5 .810 
Ery, ×109/L 9.4 1.6 7 8.0 1.2 5 .307 
Re 40.5 19.6 10 33.8 5.6 4 .267 
Leu, ×109/L 0.0061 0.0019 7 0.0077 0.0038 5 .518 
Pl, 109/L 28.70 18.77 6 31.96 14.75 5 .807 
Ne 0.257* 0.091* 11 0.474* 0.171* 7 .011* 
Ly 0.655* 0.083* 11 0.390* 0.091* 8 .001* 
Mo 0.041 0.032 11 0.030 0.019 8 .521 
Eo 0.020 0.019 11 0.040 0.041 7 .341 
Ba 0.028 0.024 11 0.059 0.045 7 .143 
Controls
tPtch−/− (19 days)
MeanDeviationnMeanDeviationnP
Hkt 0.425 0.028 7 0.409 0.062 5 .663 
Hgb, g/dL 134.0 6.0 6 131.0 18.0 5 .810 
Ery, ×109/L 9.4 1.6 7 8.0 1.2 5 .307 
Re 40.5 19.6 10 33.8 5.6 4 .267 
Leu, ×109/L 0.0061 0.0019 7 0.0077 0.0038 5 .518 
Pl, 109/L 28.70 18.77 6 31.96 14.75 5 .807 
Ne 0.257* 0.091* 11 0.474* 0.171* 7 .011* 
Ly 0.655* 0.083* 11 0.390* 0.091* 8 .001* 
Mo 0.041 0.032 11 0.030 0.019 8 .521 
Eo 0.020 0.019 11 0.040 0.041 7 .341 
Ba 0.028 0.024 11 0.059 0.045 7 .143 

Blood cell numbers were determined both by an automated hematological analyzer or by analyzing blood smears. Hkt, Ne, Ly, Mo, Eo, and Ba are given as proportions of 1.0. Re are given as the proportion of 1000 Ery.

Hkt indicates hematocrit; Hgb, hemoglobin; Ery, erythrocytes; Re, reticulocytes; Leu, leukocytes; Pl, platelets; Ne, neutrophil granulocytes; Ly, lymphocytes; Mo, monocytes; Eo, eosinophil granulocytes; and Ba, basophil granulocytes.

*

Significant differences (P value < .05 by Mann-Whitney U test) between tPtch−/− and control mice.

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