Fatal bleeding episodes in patients with acquired hemophilia A
| Time of death after presentation, d . | Site of fatal bleed . | FVIII at presentation, IU/dL . | Inhibitor titer at presentation, BU/mL . |
|---|---|---|---|
| 0 | Gastrointestinal | < 1 | Not stated |
| 2 | Gastrointestinal | 4 | 2 |
| 4 | Lung | 4 | 5 |
| 14 | Intracranial | 4 | 15 |
| 17 | Postoperative | 9 | 8 |
| 19 | Retroperitoneal | 2.3 | 18 |
| 24 | Intracranial | 9 | 1.4 |
| 66 | Internal | 5 | 219 |
| 106 | Intracranial | 4 | 6 |
| 136 | Gastrointestinal | < 1 | 109 |
| 148 | Intracranial | 2 | 14 |
| Not stated | Retroperitoneal | 12 | 4 |
| Not stated | Intracranial, retroperitoneal, gastrointestinal | 3 | 6.4 |
| Time of death after presentation, d . | Site of fatal bleed . | FVIII at presentation, IU/dL . | Inhibitor titer at presentation, BU/mL . |
|---|---|---|---|
| 0 | Gastrointestinal | < 1 | Not stated |
| 2 | Gastrointestinal | 4 | 2 |
| 4 | Lung | 4 | 5 |
| 14 | Intracranial | 4 | 15 |
| 17 | Postoperative | 9 | 8 |
| 19 | Retroperitoneal | 2.3 | 18 |
| 24 | Intracranial | 9 | 1.4 |
| 66 | Internal | 5 | 219 |
| 106 | Intracranial | 4 | 6 |
| 136 | Gastrointestinal | < 1 | 109 |
| 148 | Intracranial | 2 | 14 |
| Not stated | Retroperitoneal | 12 | 4 |
| Not stated | Intracranial, retroperitoneal, gastrointestinal | 3 | 6.4 |
Cohort of patients in whom bleeding was the primary cause of death. The time of death after presentation is shown. Although some patients had rapidly fatal bleeding, if the inhibitor was not eradicated fatal bleeding remained a risk. Fatal bleeding episodes were not related to factor VIII level or inhibitor titer at presentation.