RUNX1 mutation status is correlated to cytogenetic aberrations in the AML M0 cohort
| M0 . | RUNX1 mutation status . | P . | |
|---|---|---|---|
| Karyotype . | RUNX1-wt, n=49 . | RUNX1 mutated, n=41 . | |
| Normal | 21 | 11 | .114 |
| Complex | 10 | 2 | .031 |
| 11q23/MLL | 3 | 1 | ND |
| inv(3)t(3:3) | 2 | 0 | ND |
| -5/5q- | 0 | 1 | ND |
| -7/7q- | 2 | 2 | ND |
| +8 | 1 | 0 | ND |
| Others | 10 | 5 | .476 |
| +13 | 0 | 18* | <.001 |
| +21 | 0 | 1 | ND |
| M0 . | RUNX1 mutation status . | P . | |
|---|---|---|---|
| Karyotype . | RUNX1-wt, n=49 . | RUNX1 mutated, n=41 . | |
| Normal | 21 | 11 | .114 |
| Complex | 10 | 2 | .031 |
| 11q23/MLL | 3 | 1 | ND |
| inv(3)t(3:3) | 2 | 0 | ND |
| -5/5q- | 0 | 1 | ND |
| -7/7q- | 2 | 2 | ND |
| +8 | 1 | 0 | ND |
| Others | 10 | 5 | .476 |
| +13 | 0 | 18* | <.001 |
| +21 | 0 | 1 | ND |
ND indicates not determined.
In contrast to all other cases, the trisomy 13 subgroup was not entirely derived from a randomly selected cohort but was expanded from 9 (from the randomly selected group) to 18 samples (after the initial analysis) selected on the basis of a +13.