Most frequently reported adverse events in the phase 1 study of eltrombopag in healthy male subjects.
| Adverse event . | 5-mg dose . | 10-mg dose . | 20-mg dose . | 30-mg dose . | 50-mg dose . | 75-mg dose . | Placebo . |
|---|---|---|---|---|---|---|---|
| Headache | 2 | 4 | 0 | 1 | 1 | 3 | 2 |
| Abdominal pain/cramp | 0 | 1 | 1 | 0 | 0 | 1 | 0 |
| Sore throat | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
| Tiredness | 0 | 0 | 0 | 3 | 0 | 0 | 0 |
| Loose stools | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| Minor nose bleed | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
| Bruise | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| Subjects exposed | 9 | 9 | 9 | 9 | 10 | 9 | 18 |
| Adverse event . | 5-mg dose . | 10-mg dose . | 20-mg dose . | 30-mg dose . | 50-mg dose . | 75-mg dose . | Placebo . |
|---|---|---|---|---|---|---|---|
| Headache | 2 | 4 | 0 | 1 | 1 | 3 | 2 |
| Abdominal pain/cramp | 0 | 1 | 1 | 0 | 0 | 1 | 0 |
| Sore throat | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
| Tiredness | 0 | 0 | 0 | 3 | 0 | 0 | 0 |
| Loose stools | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| Minor nose bleed | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
| Bruise | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| Subjects exposed | 9 | 9 | 9 | 9 | 10 | 9 | 18 |
Other adverse events (≤ 1) include blurred vision, indigestion, and dermatitis.