Association of dose requirements with constitutional and genetic determinants
| . | Less than 20 mg/wk, OR (CL) . | More than 70 mg/wk, OR (CL) . |
|---|---|---|
| Age | 1.05 (1.02-1.14) | 0.93 (0.87-0.98) |
| Weight | NS | NS |
| CYP2C9*2 and *3 | 2.4 (1.3-4.6) | NS |
| VKORC1*2 | NS | NS |
| VKORC1 Asp36Tyr | NS | 13.0 (1.3-124.2) |
| . | Less than 20 mg/wk, OR (CL) . | More than 70 mg/wk, OR (CL) . |
|---|---|---|
| Age | 1.05 (1.02-1.14) | 0.93 (0.87-0.98) |
| Weight | NS | NS |
| CYP2C9*2 and *3 | 2.4 (1.3-4.6) | NS |
| VKORC1*2 | NS | NS |
| VKORC1 Asp36Tyr | NS | 13.0 (1.3-124.2) |
Dose requirements in the control group categorized as high (> 70 mg/wk) and low (< 20 mg/wk) are analyzed by the logistic regression.
NS indicates nonsignificant.