Genotypes in the warfarin-resistant and -sensitive patient groups
| Patient no. . | Sex . | Age, y . | Weight, kg . | Dose, mg/wk . | CYP2C9 genotypes . | VKORC1 haplotypes . | VKORC1 Asp36Tyr . |
|---|---|---|---|---|---|---|---|
| Warfarin-resistant group | |||||||
| 1 | F | 42 | 52 | 185 | *1/*1 | *1/*3 | Wt/Mut |
| 2 | M | 60 | 90 | 140 | *1/*1 | *1/*4 | Wt/Mut |
| 3 | F | 84 | 51 | 138 | *1/*1 | *1/*4 | Wt/Mut |
| 4 | F | 53 | 70 | 135 | *1/*2 | *1/*4 | Wt/Mut |
| 5 | M | 53 | 90 | 123 | *1/*1 | *1/*2 | Wt/Mut |
| 6 | F | 34 | 82 | 123 | *1/*1 | *1/*3 | Wt/Mut |
| 7 | M | 60 | 66 | 115 | *1/*1 | *3/*4 | Wt/Wt |
| 8 | M | 32 | 80 | 110 | *1/*1 | *3/*3 | Wt/Wt |
| 9 | F | 35 | 65 | 105 | *1/*1 | *3/*4 | Wt/Wt |
| 10 | F | 55 | 72 | 95 | *1/*1 | *4/*4 | Wt/Wt |
| 11 | F | 40 | 53 | 95 | *1/*1 | *3/*4 | Wt/Wt |
| 12 | M | 55 | 91 | 80 | *1/*3 | *1/*2 | Wt/Mut |
| 13 | F | 43 | 55 | 80 | *1/*1 | *2/*3 | Wt/Wt |
| 14 | F | 48 | 65 | 80 | *1/*1 | *2/*3 | Wt/Wt |
| 15 | F | 31 | 80 | 88 | *1/*1 | *3/*3 | Wt/Wt |
| Warfarin-sensitive group | |||||||
| 1 | M | 80 | 76 | 13 | *1/*3 | *2/*2 | Wt/Wt |
| 2 | M | 55 | 74 | 12 | *1/*1 | *2/*2 | Wt/Wt |
| 3 | M | 60 | 70 | 12 | *1/*3 | *2/*2 | Wt/Wt |
| 4 | F | 59 | 65 | 12 | *1/*3 | *2/*2 | Wt/Wt |
| 5 | M | 82 | 71 | 11 | *1/*1 | *2/*2 | Wt/Wt |
| 6 | M | 78 | 70 | 10 | *1/*2 | *2/*3 | Wt/Wt |
| 7 | F | 69 | 68 | 7 | *3/*3 | *1/*3 | Wt/Wt |
| 8 | M | 85 | 88 | 7 | *3/*3 | *2/*4 | Wt/Wt |
| Patient no. . | Sex . | Age, y . | Weight, kg . | Dose, mg/wk . | CYP2C9 genotypes . | VKORC1 haplotypes . | VKORC1 Asp36Tyr . |
|---|---|---|---|---|---|---|---|
| Warfarin-resistant group | |||||||
| 1 | F | 42 | 52 | 185 | *1/*1 | *1/*3 | Wt/Mut |
| 2 | M | 60 | 90 | 140 | *1/*1 | *1/*4 | Wt/Mut |
| 3 | F | 84 | 51 | 138 | *1/*1 | *1/*4 | Wt/Mut |
| 4 | F | 53 | 70 | 135 | *1/*2 | *1/*4 | Wt/Mut |
| 5 | M | 53 | 90 | 123 | *1/*1 | *1/*2 | Wt/Mut |
| 6 | F | 34 | 82 | 123 | *1/*1 | *1/*3 | Wt/Mut |
| 7 | M | 60 | 66 | 115 | *1/*1 | *3/*4 | Wt/Wt |
| 8 | M | 32 | 80 | 110 | *1/*1 | *3/*3 | Wt/Wt |
| 9 | F | 35 | 65 | 105 | *1/*1 | *3/*4 | Wt/Wt |
| 10 | F | 55 | 72 | 95 | *1/*1 | *4/*4 | Wt/Wt |
| 11 | F | 40 | 53 | 95 | *1/*1 | *3/*4 | Wt/Wt |
| 12 | M | 55 | 91 | 80 | *1/*3 | *1/*2 | Wt/Mut |
| 13 | F | 43 | 55 | 80 | *1/*1 | *2/*3 | Wt/Wt |
| 14 | F | 48 | 65 | 80 | *1/*1 | *2/*3 | Wt/Wt |
| 15 | F | 31 | 80 | 88 | *1/*1 | *3/*3 | Wt/Wt |
| Warfarin-sensitive group | |||||||
| 1 | M | 80 | 76 | 13 | *1/*3 | *2/*2 | Wt/Wt |
| 2 | M | 55 | 74 | 12 | *1/*1 | *2/*2 | Wt/Wt |
| 3 | M | 60 | 70 | 12 | *1/*3 | *2/*2 | Wt/Wt |
| 4 | F | 59 | 65 | 12 | *1/*3 | *2/*2 | Wt/Wt |
| 5 | M | 82 | 71 | 11 | *1/*1 | *2/*2 | Wt/Wt |
| 6 | M | 78 | 70 | 10 | *1/*2 | *2/*3 | Wt/Wt |
| 7 | F | 69 | 68 | 7 | *3/*3 | *1/*3 | Wt/Wt |
| 8 | M | 85 | 88 | 7 | *3/*3 | *2/*4 | Wt/Wt |
CYP2C9*1,*2, and *3 are consistent with the conventional nomenclature. VKORC1*2, *3, and *4 correspond to 6853G>C, 9041G>A, and 6009C>T tag-SNPs, respectively. Mut (mutants) are heterozygotes for VKORC1 5417G>T (Asp36Tyr).
Wt indicates wild type.