Whole-blood clotting time and clot rate in VWF−/− mice with or without r-hu-FVIII (measurement performed 20 minutes after infusion of r-hu-FVIII)
| Genotype . | No. mice . | r-hu-FVIII . | Clotting time, s . | Clotting time, P value from WT . | Clot rate . | Clot rate, P value from WT . |
|---|---|---|---|---|---|---|
| WT | 7 | − | 259 ± 9 | — | 10 ± 1 | — |
| VWF−/− | 7 | − | 318 ± 7 | <.001 | 7 ± 1 | <.05 |
| VWF−/− | 6 | + | 236 ± 11 | .16 | 10 ± 1 | .58 |
| Genotype . | No. mice . | r-hu-FVIII . | Clotting time, s . | Clotting time, P value from WT . | Clot rate . | Clot rate, P value from WT . |
|---|---|---|---|---|---|---|
| WT | 7 | − | 259 ± 9 | — | 10 ± 1 | — |
| VWF−/− | 7 | − | 318 ± 7 | <.001 | 7 ± 1 | <.05 |
| VWF−/− | 6 | + | 236 ± 11 | .16 | 10 ± 1 | .58 |
— indicates not applicable.