Functional studies in carriers and noncarriers of the antithrombin Cambridge II (A384S) variant
| . | Noncarriers . | All carriers . | P . | Heterozygous . | Homozygous . | P . |
|---|---|---|---|---|---|---|
| No. of controls | 17 | 20 | 16 | 4 | ||
| AT antigen levels (range) | 97.9 ± 14.2 (83.6-136.0) | 96.1 ± 12.6 (64.2-131.2) | .693 | 96.3 ± 13.8 (64.2-131.2) | 95.4 ± 7.2 (88.3-105.2) | .895 |
| Anti-Xa + UFH (range) | 100.2 ± 4.3 (92.3-106.1) | 98.5 ± 10.7 (75.7-108.5) | .555 | 100.2 ± 10.3 (75.7-108.5) | 91.7 ± 10.5 (82.3-106.8) | .159 |
| Anti-Xa + LMWH (range) | 100.1 ± 8.0 (85.0-1116.9) | 97.6 ± 11.8 (70.3-111.3) | .463 | 98.8 ± 11.2 (70.3-111.3) | 92.6 ± 14.5 (75.3-108.9) | .355 |
| Anti-IIa + UFH (range) | 100.0 ± 7.9 (87.5-118.0) | 79.3 ± 7.8 (66.9-90.8) | < .001 | 81.8 ± 6.6 (70.6-90.8) | 69.5 ± 2.4 (66.9-72.6) | .002 |
| Anti-IIa + LMWH (range) | 100.6 ± 7.5 (84.9-113.2) | 90.1 ± 9.5 (73.4-107.6) | < .001 | 92.4 ± 9.1 (73.4-107.6) | 81.0 ± 3.6 (76.5-85.1) | .027 |
| . | Noncarriers . | All carriers . | P . | Heterozygous . | Homozygous . | P . |
|---|---|---|---|---|---|---|
| No. of controls | 17 | 20 | 16 | 4 | ||
| AT antigen levels (range) | 97.9 ± 14.2 (83.6-136.0) | 96.1 ± 12.6 (64.2-131.2) | .693 | 96.3 ± 13.8 (64.2-131.2) | 95.4 ± 7.2 (88.3-105.2) | .895 |
| Anti-Xa + UFH (range) | 100.2 ± 4.3 (92.3-106.1) | 98.5 ± 10.7 (75.7-108.5) | .555 | 100.2 ± 10.3 (75.7-108.5) | 91.7 ± 10.5 (82.3-106.8) | .159 |
| Anti-Xa + LMWH (range) | 100.1 ± 8.0 (85.0-1116.9) | 97.6 ± 11.8 (70.3-111.3) | .463 | 98.8 ± 11.2 (70.3-111.3) | 92.6 ± 14.5 (75.3-108.9) | .355 |
| Anti-IIa + UFH (range) | 100.0 ± 7.9 (87.5-118.0) | 79.3 ± 7.8 (66.9-90.8) | < .001 | 81.8 ± 6.6 (70.6-90.8) | 69.5 ± 2.4 (66.9-72.6) | .002 |
| Anti-IIa + LMWH (range) | 100.6 ± 7.5 (84.9-113.2) | 90.1 ± 9.5 (73.4-107.6) | < .001 | 92.4 ± 9.1 (73.4-107.6) | 81.0 ± 3.6 (76.5-85.1) | .027 |
Values (mean ± SD) represent percentages of the result obtained in a pool of 100 healthy controls, except where otherwise indicated.
AT indicates antithrombin; UFH, unfractionated heparin; LMWH, low-molecular-weight heparin.