Combination indices of carfilzomib and Dex for RPMI 8226 cells
| Carfilzomib (nM) . | Dex (μM) . | ||
|---|---|---|---|
| 1 . | 5 . | 10 . | |
| 1 | 0.1 | 0.2 | 0.1 |
| 2.5 | 0.3 | 0.3 | 0.3 |
| 5 | 0.5 | 0.5 | 0.5 |
| 10 | 0.8 | 0.9 | 0.9 |
| Carfilzomib (nM) . | Dex (μM) . | ||
|---|---|---|---|
| 1 . | 5 . | 10 . | |
| 1 | 0.1 | 0.2 | 0.1 |
| 2.5 | 0.3 | 0.3 | 0.3 |
| 5 | 0.5 | 0.5 | 0.5 |
| 10 | 0.8 | 0.9 | 0.9 |
Combination indices of RPMI 8226 cells treated for 48 hours with the indicated concentrations of carfilzomib and Dex are shown. Data were analyzed using Calcusyn (version 2) software (BioSoft, Milltown, NJ). The combination index (CI) is a quantitative measure of the degree of drug interaction, with a CI less than 1 indicating synergy, a CI of 1 indicating additive effects, and a CI over 1 indicating antagonist.