Mutation numbers and prevalence of TP53 somatic mutations in lymphoid malignancies in IARC database
| Neoplasms . | Sample/mutation associations* . | Mutation variants† . | Prevalence‡ . |
|---|---|---|---|
| B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL) | 193 | 149 | 10.0% (215/2142) |
| Prolymphocytic leukemia (PLL) | 11 | 11 | 23.5% (12/51) |
| Follicular lymphoma (FL) | 61 | 51 | 11.5% (45/393) |
| Mantle cell lymphoma (MCL) | 56 | 44 | 16.9% (44/260) |
| Marginal zone B-cell lymphoma (MZL) | 46 | 34 | 21.6% (47/218) |
| Diffuse large B-cell lymphoma (DLBCL) | 241 | 165 | 19.7% (124/630) |
| Burkitt lymphoma/Burkitt cell leukemia (BL/L) | 126 | 79 | 20.8% (72/346) |
| Primary effusion lymphoma (PEL) | 5 | 5 | 6.3% (1/16) |
| Mature T-cell lymphoma | 23 | 21 | 42.9% (12/28) |
| Angioimmunoblastic T-cell lymphoma (AILT) | 1 | 1 | N/A |
| T-cell large granular lymphocytic leukemia (LGL) | 4 | 4 | N/A |
| Anaplastic large cell lymphoma, T cell and null cell type (ALCL) | 6 | 6 | 7.3% (4/55) |
| Adult T-cell leukemia/lymphoma (ATCL) | 42 | 40 | 30.7% (23/75) |
| NK/T-cell lymphoma/leukemia | 8 | 7 | 40.1% (109/272) |
| Hodgkin lymphoma (HL) | 16 | 15 | 12.1% (4/33) |
| Plasma cell leukemia/plasmacytoma/multiple myeloma (PCL/PC/MM) | 52 | 42 | 6.1% (34/556) |
| Hairy cell leukemia (HCL) | 31 | 18 | 26.1% (18/69) |
| Neoplasms . | Sample/mutation associations* . | Mutation variants† . | Prevalence‡ . |
|---|---|---|---|
| B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL) | 193 | 149 | 10.0% (215/2142) |
| Prolymphocytic leukemia (PLL) | 11 | 11 | 23.5% (12/51) |
| Follicular lymphoma (FL) | 61 | 51 | 11.5% (45/393) |
| Mantle cell lymphoma (MCL) | 56 | 44 | 16.9% (44/260) |
| Marginal zone B-cell lymphoma (MZL) | 46 | 34 | 21.6% (47/218) |
| Diffuse large B-cell lymphoma (DLBCL) | 241 | 165 | 19.7% (124/630) |
| Burkitt lymphoma/Burkitt cell leukemia (BL/L) | 126 | 79 | 20.8% (72/346) |
| Primary effusion lymphoma (PEL) | 5 | 5 | 6.3% (1/16) |
| Mature T-cell lymphoma | 23 | 21 | 42.9% (12/28) |
| Angioimmunoblastic T-cell lymphoma (AILT) | 1 | 1 | N/A |
| T-cell large granular lymphocytic leukemia (LGL) | 4 | 4 | N/A |
| Anaplastic large cell lymphoma, T cell and null cell type (ALCL) | 6 | 6 | 7.3% (4/55) |
| Adult T-cell leukemia/lymphoma (ATCL) | 42 | 40 | 30.7% (23/75) |
| NK/T-cell lymphoma/leukemia | 8 | 7 | 40.1% (109/272) |
| Hodgkin lymphoma (HL) | 16 | 15 | 12.1% (4/33) |
| Plasma cell leukemia/plasmacytoma/multiple myeloma (PCL/PC/MM) | 52 | 42 | 6.1% (34/556) |
| Hairy cell leukemia (HCL) | 31 | 18 | 26.1% (18/69) |
Sample/mutation association numbers for different malignancies are total numbers of mutation_IDs (unique identifier of a sample/mutation association) in IARC database.
Numbers of mutation variants are those of somatic MUT_IDs (unique identifier of each gene variation) for different malignancies in IARC database.
Prevalence (%) for different malignancies is calculated as the number of cases with mutations divided by the total number of cases analyzed for different malignancies in IARC prevalence dataset.