Comparison of the gene-expression pattern of lipid metabolism and immune response–related genes
| . | Immune response . | Lipid metabolism . | ||
|---|---|---|---|---|
| P . | Annotated genes . | P . | Annotated genes . | |
| 6 h, up-regulated by RSG; 203 probe sets, 80 annotated genes | NS | SPN, IL7R, BCL2, SEMA3C, TLR4, SAMHD1 | <.001 | LYPLA3, ACAA2, CD36, ECH1, FABP5, APOC1, SCARB1, ANGPTL4, CPT1A, MLYCD, SCD, PPAP2B, ABCG1, PLCL1, HADHSC |
| 24 h, up-regulated by RSG; 210 probe sets, 84 annotated genes | <.001 | MGLL, C1QB, C1QG, OAS1, OAS3, C1QA, TLR4, GBP2, TRIM22, OAS2, IL21R, GBP1, IL7R, ALOX5, CD1D, CCL15, MX2, NCK2, APOL3, SAMHD1 | .006 | MGLL, DDHD1, PLTP, ECH1, APOC1, PHYH, SCARB1, ACADVL, ALOX5, ACSL1, PPAP2B, SCD, HADHSC |
| 5 d, up-regulated by RSG; 395 probe sets, 157 annotated genes | .011 | MR1, MGLL, OAS1, SPG3A, OAS3, C3, TLR4, ADA, AOC3, CCL5, COL4A3BP, CCRL2, IFIT2, LTB4R, GPR65, IL7R, CD1D, S100A8, CD164, FOS, SPON2, ITGAL, C4A, S100A9 | .019 | MGLL, CD36, PCCA, PPP2R1B, ECH1, DHRS3, VLDLR, PECR, APOC1, ASAH1, PC, ACSL1, SCD, PPAP2B, HSD11B1, FDX1, HADHSC |
| 6 h, down-regulated by RSG; 33 probe sets, 12 annotated genes | NS | HAMP, CCL1 | ||
| 24 h, down-regulated by RSG; 144 probe sets, 72 annotated genes | NS | PPBP, BST1, HPSE, CD1B, FCAR, ENTPD1, CD1C, CD226, ALOX5AP, CD1E, IL1R2, CD1A, IL1RAP | NS | ALOX5AP |
| 5 d, down-regulatedby RSG; 406 probesets, 162 annotatedgenes | .036 | PPBP, CSF2RB, BCL6, CD1B, CCL4, CD1C, CCR7, TNFRSF4, RGS1, IRF4, INHBA, SERPINA1, TLR6, PTGER4, CD80, CD1E, IL1R2, IL1R1, MMP25, IFI16, CD1A, IL1RAP | NS | AGPAT1, ISYNA1, LTC4S, PLA2G4A, PPAP2A, OSBPL3 |
| . | Immune response . | Lipid metabolism . | ||
|---|---|---|---|---|
| P . | Annotated genes . | P . | Annotated genes . | |
| 6 h, up-regulated by RSG; 203 probe sets, 80 annotated genes | NS | SPN, IL7R, BCL2, SEMA3C, TLR4, SAMHD1 | <.001 | LYPLA3, ACAA2, CD36, ECH1, FABP5, APOC1, SCARB1, ANGPTL4, CPT1A, MLYCD, SCD, PPAP2B, ABCG1, PLCL1, HADHSC |
| 24 h, up-regulated by RSG; 210 probe sets, 84 annotated genes | <.001 | MGLL, C1QB, C1QG, OAS1, OAS3, C1QA, TLR4, GBP2, TRIM22, OAS2, IL21R, GBP1, IL7R, ALOX5, CD1D, CCL15, MX2, NCK2, APOL3, SAMHD1 | .006 | MGLL, DDHD1, PLTP, ECH1, APOC1, PHYH, SCARB1, ACADVL, ALOX5, ACSL1, PPAP2B, SCD, HADHSC |
| 5 d, up-regulated by RSG; 395 probe sets, 157 annotated genes | .011 | MR1, MGLL, OAS1, SPG3A, OAS3, C3, TLR4, ADA, AOC3, CCL5, COL4A3BP, CCRL2, IFIT2, LTB4R, GPR65, IL7R, CD1D, S100A8, CD164, FOS, SPON2, ITGAL, C4A, S100A9 | .019 | MGLL, CD36, PCCA, PPP2R1B, ECH1, DHRS3, VLDLR, PECR, APOC1, ASAH1, PC, ACSL1, SCD, PPAP2B, HSD11B1, FDX1, HADHSC |
| 6 h, down-regulated by RSG; 33 probe sets, 12 annotated genes | NS | HAMP, CCL1 | ||
| 24 h, down-regulated by RSG; 144 probe sets, 72 annotated genes | NS | PPBP, BST1, HPSE, CD1B, FCAR, ENTPD1, CD1C, CD226, ALOX5AP, CD1E, IL1R2, CD1A, IL1RAP | NS | ALOX5AP |
| 5 d, down-regulatedby RSG; 406 probesets, 162 annotatedgenes | .036 | PPBP, CSF2RB, BCL6, CD1B, CCL4, CD1C, CCR7, TNFRSF4, RGS1, IRF4, INHBA, SERPINA1, TLR6, PTGER4, CD80, CD1E, IL1R2, IL1R1, MMP25, IFI16, CD1A, IL1RAP | NS | AGPAT1, ISYNA1, LTC4S, PLA2G4A, PPAP2A, OSBPL3 |
Microarray gene lists were analyzed with Cytoscape/BiNGO software to assess Gene Ontology (GO) category enrichment. The corrected P values are also indicated. These were calculated by Cytoscape/BiNGO using a hypergeometrical test to assess whether the GO categories were overrepresented or not.
NS indicates nonsignificant.