Patient characteristics
| Demographic/characteristic . | Total patients (N = 51) . |
|---|---|
| Sex, n (%) | |
| Female | 22 (43) |
| Male | 29 (57) |
| Age, median (range), y | 50.0 (19-81) |
| Disease at study entry, n (%) | |
| AML (n = 43) | |
| MLL-r | 33 (65) |
| MLL-PTD | 2 (4) |
| MLL-r and MLL-PTD | 2 (4) |
| MLL-wt | 6 (12) |
| ALL (n = 6) | |
| MLL-r | 4 (8) |
| MLL-wt | 2 (4) |
| MLL (n = 1) | |
| MLL-PTD | 1 (2) |
| CMML (n = 1) | |
| MLL-wt | 1 (2) |
| Prior systemic therapy regimens, n (%) | |
| 1 | 2 (4) |
| 2 | 11 (22) |
| ≥3 | 38 (75) |
| Prior allogeneic hematopoietic cell transplants, n (%) | |
| 1 | 19 (37) |
| 2 | 1 (2) |
| Demographic/characteristic . | Total patients (N = 51) . |
|---|---|
| Sex, n (%) | |
| Female | 22 (43) |
| Male | 29 (57) |
| Age, median (range), y | 50.0 (19-81) |
| Disease at study entry, n (%) | |
| AML (n = 43) | |
| MLL-r | 33 (65) |
| MLL-PTD | 2 (4) |
| MLL-r and MLL-PTD | 2 (4) |
| MLL-wt | 6 (12) |
| ALL (n = 6) | |
| MLL-r | 4 (8) |
| MLL-wt | 2 (4) |
| MLL (n = 1) | |
| MLL-PTD | 1 (2) |
| CMML (n = 1) | |
| MLL-wt | 1 (2) |
| Prior systemic therapy regimens, n (%) | |
| 1 | 2 (4) |
| 2 | 11 (22) |
| ≥3 | 38 (75) |
| Prior allogeneic hematopoietic cell transplants, n (%) | |
| 1 | 19 (37) |
| 2 | 1 (2) |
MLL-r and MLL-PTD were identified locally through standard karyotyping or 11q23 FISH (MLL-r) or NGS- or PCR-based methods (MLL-PTD). MLL-wt = no MLL rearrangement detected.