Table 1. Phenotype comparison of CUX1... | American Society of Hematology

Table 1.

Phenotype comparison of CUX1 knockdown mouse models

Phenotype	Cux1^mid	Cux1^low	Cux1^mid BMT	Cux1^low BMT
CUX1 protein (% of normal)	∼54	∼12	∼54	∼12
Disease	MDS (RCMD)	MDS/MPN (CMML/JMML)	MDS (RCMD)	MDS (RCMD)
Survival (days of dox)	Normal	275	370	262
Splenomegaly	Mild	Yes	No	No
BM cellularity	Normal	Increased	Decreased	Decreased
RBCs	Decreased	Decreased	Slightly decreased	Decreased
Platelets	Increased	Normal or increased	Decreased	Decreased
WBCs	Normal	Increased	Normal	Slightly decreased
Granulocytes	Increased PB %	Increased	Increased PB %	Increased PB %
Monocytes	Increased	Increased	Increased PB %	Normal
B cells	Decreased	Decreased	Slightly decreased	Decreased
T cells	Normal	Increased	Normal	Normal
Dysplasia	Trilineage	Trilineage	Trilineage	Trilineage
LT-HSCs	Normal	Normal	Decreased in second transplant	Decreased in first and second transplants

Phenotype	Cux1^mid	Cux1^low	Cux1^mid BMT	Cux1^low BMT
CUX1 protein (% of normal)	∼54	∼12	∼54	∼12
Disease	MDS (RCMD)	MDS/MPN (CMML/JMML)	MDS (RCMD)	MDS (RCMD)
Survival (days of dox)	Normal	275	370	262
Splenomegaly	Mild	Yes	No	No
BM cellularity	Normal	Increased	Decreased	Decreased
RBCs	Decreased	Decreased	Slightly decreased	Decreased
Platelets	Increased	Normal or increased	Decreased	Decreased
WBCs	Normal	Increased	Normal	Slightly decreased
Granulocytes	Increased PB %	Increased	Increased PB %	Increased PB %
Monocytes	Increased	Increased	Increased PB %	Normal
B cells	Decreased	Decreased	Slightly decreased	Decreased
T cells	Normal	Increased	Normal	Normal
Dysplasia	Trilineage	Trilineage	Trilineage	Trilineage
LT-HSCs	Normal	Normal	Decreased in second transplant	Decreased in first and second transplants