Proposed unifying nomenclature and examples of immunodeficiency-associated LPDs
| 3-Part unifying nomenclature . | ||
|---|---|---|
| Name of lesion . | Viral status . | Specific immunodeficiency setting . |
| B-cell hyperplasia (eg, plasmacytic hyperplasia) | eg, EBV+/−, HHV8+/− | eg, Posttransplant (solid organ), iatrogenic (methotrexate), immune senescence |
| Polymorphic B-cell lymphoproliferations (eg, mucocutaneous ulcer) | ||
| Lymphoma (WHO terminology) (eg, diffuse large B-cell lymphoma, Anaplastic large cell lymphoma, ALK−) | ||
| 3-Part unifying nomenclature . | ||
|---|---|---|
| Name of lesion . | Viral status . | Specific immunodeficiency setting . |
| B-cell hyperplasia (eg, plasmacytic hyperplasia) | eg, EBV+/−, HHV8+/− | eg, Posttransplant (solid organ), iatrogenic (methotrexate), immune senescence |
| Polymorphic B-cell lymphoproliferations (eg, mucocutaneous ulcer) | ||
| Lymphoma (WHO terminology) (eg, diffuse large B-cell lymphoma, Anaplastic large cell lymphoma, ALK−) | ||
| Examples of diagnostic labels . | |
|---|---|
| Proposed unifying nomenclature . | WHO 2016 nomenclature . |
| Plasmacytic hyperplasia, EBV+, posttransplant (solid organ) | Plasmacytic hyperplasia, nondestructive posttransplant LPD |
| Polymorphic B-LPD, EBV+, iatrogenic (methotrexate) | Polymorphic LPD resembling polymorphic posttransplant LPD |
| Mucocutaneous ulcer, EBV+, primary immunodeficiency (CHARGE syndrome) | EBV+ mucocutaneous ulcer |
| Diffuse large B-cell lymphoma, EBV−, HIV infection | Diffuse large B-cell lymphoma |
| Diffuse large B-cell lymphoma, T-cell/histiocyte-rich, EBV+, immune senescence | EBV+ diffuse large B-cell lymphoma |
| Primary effusion lymphoma, HHV8+, EBV+, HIV infection | Primary effusion lymphoma |
| Examples of diagnostic labels . | |
|---|---|
| Proposed unifying nomenclature . | WHO 2016 nomenclature . |
| Plasmacytic hyperplasia, EBV+, posttransplant (solid organ) | Plasmacytic hyperplasia, nondestructive posttransplant LPD |
| Polymorphic B-LPD, EBV+, iatrogenic (methotrexate) | Polymorphic LPD resembling polymorphic posttransplant LPD |
| Mucocutaneous ulcer, EBV+, primary immunodeficiency (CHARGE syndrome) | EBV+ mucocutaneous ulcer |
| Diffuse large B-cell lymphoma, EBV−, HIV infection | Diffuse large B-cell lymphoma |
| Diffuse large B-cell lymphoma, T-cell/histiocyte-rich, EBV+, immune senescence | EBV+ diffuse large B-cell lymphoma |
| Primary effusion lymphoma, HHV8+, EBV+, HIV infection | Primary effusion lymphoma |