Demographic and entry characteristics of the study cohort compared with all deliveries during the recruitment period
| . | All deliveries in the study period . | Women enrolled into the study . | Women with ongoing bleeding* . |
|---|---|---|---|
| Number of deliveries | 6187 | 356 | 110 |
| Age (y) | |||
| Mean (SD) | 29 (5.9) | 30 (5.8) | 30 (5.8) |
| Median (25th-75th centiles) | 29 (25-33) | 30 (26-34) | 31 (27-34) |
| BMI (kg/m2) | |||
| Mean (SD) | 28 (5.9) | 27 (5.7) | 27 (5.7) |
| Median (25th-75th centiles) | 25 (22-29) | 26 (23-30) | 26 (23-29) |
| Delivery, n (%) | |||
| Induction of labor | |||
| Spontaneous | 3918 (64) | 166 (48) | 37 (34) |
| Induced | 1339 (22) | 96 (28) | 53 (48) |
| No labor | 874 (14) | 85 (25) | 20 (18) |
| Uncomplicated vaginal | 3854 (62) | 87 (25) | 42 (38) |
| Instrumental vaginal | 901(15) | 74 (21) | 20 (18) |
| Elective cesarean | 641 (10) | 62 (18) | 12 (11) |
| Nonelective cesarean | 790 (13) | 124 (36) | 36 (33) |
| Primary cause of PPH, n (%) | n = 347 | n = 109 | |
| Uterine atony | NA | 146 (42) | 50 (46) |
| Surgical bleeding or genital tract trauma | NA | 126 (36) | 19 (17) |
| Adherent or retained placenta | NA | 36 (10) | 17 (15) |
| Placental abruption | NA | 14 (4) | 9 (8) |
| Placenta praevia | NA | 8 (2) | 5 (5) |
| No identified cause | NA | 13 (4) | 6 (5) |
| Ruptured or dehisced uterus | NA | 3 (0.9) | 3 (3) |
| Anticoagulation | NA | 1 (0.2) | 1 (1) |
| Blood loss | |||
| Estimated blood loss at study entry (mL), median (25th-75th centiles) | NA | 1200 (1000-1500) | 1200 (1000-1500) |
| Total bleed volume (mL), median (25th-75th centiles) | 350 (200-500) | 1500 (1200-2000) | 2000 (1513-2738) |
| Hematologic tests at study entry | |||
| Hb at study entry (g/L), median (25th-75th centiles) | NA | 103 (93-113) | 101 (88-111) |
| Fibrinogen at study entry (g/L), median (25th-75th centiles) | NA | 3.8 (3.1-4.5) | 3.4 (2.9-4.1) |
| Fibtem A5 at study entry (mm), median (25th-75th centiles) | NA | 19 (16-23) | 18 (14-21) |
| Transfusions | |||
| Transfused any blood product, n (%) | ND | 106 (30) | 63 (57) |
| Transfused ≥4 U RBCs, n (%) | ND | 32 (9.0) | 30 (27) |
| Transfused ≥8 U RBCs + FFP + platelets, n (%) | ND | 26 (7.5) | 24 (22) |
| . | All deliveries in the study period . | Women enrolled into the study . | Women with ongoing bleeding* . |
|---|---|---|---|
| Number of deliveries | 6187 | 356 | 110 |
| Age (y) | |||
| Mean (SD) | 29 (5.9) | 30 (5.8) | 30 (5.8) |
| Median (25th-75th centiles) | 29 (25-33) | 30 (26-34) | 31 (27-34) |
| BMI (kg/m2) | |||
| Mean (SD) | 28 (5.9) | 27 (5.7) | 27 (5.7) |
| Median (25th-75th centiles) | 25 (22-29) | 26 (23-30) | 26 (23-29) |
| Delivery, n (%) | |||
| Induction of labor | |||
| Spontaneous | 3918 (64) | 166 (48) | 37 (34) |
| Induced | 1339 (22) | 96 (28) | 53 (48) |
| No labor | 874 (14) | 85 (25) | 20 (18) |
| Uncomplicated vaginal | 3854 (62) | 87 (25) | 42 (38) |
| Instrumental vaginal | 901(15) | 74 (21) | 20 (18) |
| Elective cesarean | 641 (10) | 62 (18) | 12 (11) |
| Nonelective cesarean | 790 (13) | 124 (36) | 36 (33) |
| Primary cause of PPH, n (%) | n = 347 | n = 109 | |
| Uterine atony | NA | 146 (42) | 50 (46) |
| Surgical bleeding or genital tract trauma | NA | 126 (36) | 19 (17) |
| Adherent or retained placenta | NA | 36 (10) | 17 (15) |
| Placental abruption | NA | 14 (4) | 9 (8) |
| Placenta praevia | NA | 8 (2) | 5 (5) |
| No identified cause | NA | 13 (4) | 6 (5) |
| Ruptured or dehisced uterus | NA | 3 (0.9) | 3 (3) |
| Anticoagulation | NA | 1 (0.2) | 1 (1) |
| Blood loss | |||
| Estimated blood loss at study entry (mL), median (25th-75th centiles) | NA | 1200 (1000-1500) | 1200 (1000-1500) |
| Total bleed volume (mL), median (25th-75th centiles) | 350 (200-500) | 1500 (1200-2000) | 2000 (1513-2738) |
| Hematologic tests at study entry | |||
| Hb at study entry (g/L), median (25th-75th centiles) | NA | 103 (93-113) | 101 (88-111) |
| Fibrinogen at study entry (g/L), median (25th-75th centiles) | NA | 3.8 (3.1-4.5) | 3.4 (2.9-4.1) |
| Fibtem A5 at study entry (mm), median (25th-75th centiles) | NA | 19 (16-23) | 18 (14-21) |
| Transfusions | |||
| Transfused any blood product, n (%) | ND | 106 (30) | 63 (57) |
| Transfused ≥4 U RBCs, n (%) | ND | 32 (9.0) | 30 (27) |
| Transfused ≥8 U RBCs + FFP + platelets, n (%) | ND | 26 (7.5) | 24 (22) |
No data were available on mode of delivery for 9 women entering the study and 1 woman in the all-deliveries group. No data were available on induction of labor in 9 women entered in the study and 56 women in the all-deliveries group.
NA, not applicable; ND, no data.
Defined as at least 250 mL additional bleeding after enrolment.