Table 4. Association between PRS and GEC... | American Society of Hematology

Table 4.

Association between PRS and GEC CLL/MBL risk compared with GEC controls

	Controls (N = 83)		CLL (N = 135)		CLL vs controls*			Controls (N = 58)		MBL (N = 95)		MBL vs controls†
PRS (range)‡	N	%	N	%	OR§	95% CI	P	N	%	N	%	OR§	95% CI	P
Q1 (4.32-6.80)	12	14.5	2	1.5	0.2	0.03-1.14	.07	7	12.1	2	2.1	0.42	0.06-2.87	.38
Q2 (6.80-7.32)	10	12.0	12	8.9	1.45	0.41-5.09	.57	8	13.8	6	6.3	1.11	0.24-5.11	.89
Q3 (7.32-7.77)	15	18.1	15	11.1	Ref	—	—	12	20.7	11	11.6	Ref	—	—
Q4 (7.77-8.28)	15	18.1	24	17.8	2.03	0.69-5.94	.20	10	17.2	19	20.0	3.15	0.85-11.7	.09
Q5 (8.28-11.31)	31	37.3	82	60.7	3.51	1.39-8.86	.008	21	36.2	57	60.0	4.36	1.45-13.1	.009
Continuous					2.44	1.65-3.62	9.00 × 10⁻⁶					2.30	1.44-3.67	.001
PRS (median)	7.96		8.47					7.90		8.40
c-statistics					0.798	0.74-0.85						0.773	0.70-0.85

	Controls (N = 83)		CLL (N = 135)		CLL vs controls*			Controls (N = 58)		MBL (N = 95)		MBL vs controls†
PRS (range)‡	N	%	N	%	OR§	95% CI	P	N	%	N	%	OR§	95% CI	P
Q1 (4.32-6.80)	12	14.5	2	1.5	0.2	0.03-1.14	.07	7	12.1	2	2.1	0.42	0.06-2.87	.38
Q2 (6.80-7.32)	10	12.0	12	8.9	1.45	0.41-5.09	.57	8	13.8	6	6.3	1.11	0.24-5.11	.89
Q3 (7.32-7.77)	15	18.1	15	11.1	Ref	—	—	12	20.7	11	11.6	Ref	—	—
Q4 (7.77-8.28)	15	18.1	24	17.8	2.03	0.69-5.94	.20	10	17.2	19	20.0	3.15	0.85-11.7	.09
Q5 (8.28-11.31)	31	37.3	82	60.7	3.51	1.39-8.86	.008	21	36.2	57	60.0	4.36	1.45-13.1	.009
Continuous					2.44	1.65-3.62	9.00 × 10⁻⁶					2.30	1.44-3.67	.001
PRS (median)	7.96		8.47					7.90		8.40
c-statistics					0.798	0.74-0.85						0.773	0.70-0.85

Ref, reference.

CLLs and controls are from unrelated families.

MBLs and controls are from unrelated families.

Quintiles based on 7983 controls from NHL GWAS.

Adjusted for age, sex, socioeconomic status, and study.